Introduction

In the realm of diabetes management, combining multiple medications to control blood sugar levels effectively is common practice. One such combination medication is GLIMITERIS TRIO 0.5/0.2/500, which combines three potent agents: Glimepiride 0.5 mg, Voglibose 0.2 mg, and Metformin Hydrochloride (SR) 500 mg. Each of these components plays a unique role in managing Type 2 diabetes, helping to regulate blood sugar levels through different mechanisms.

This article will dive into the key aspects of GLIMITERIS TRIO, including its ingredients, uses, dosage, side effects, and more. By the end of this guide, you’ll have a comprehensive understanding of why GLIMITERIS TRIO is a popular choice for treating diabetes.

Key Ingredients of GLIMITERIS TRIO 0.5/0.2/500

The combination of Glimepiride, Voglibose, and Metformin Hydrochloride (SR) forms the basis of GLIMITERIS TRIO tablets. Let’s look at each ingredient in detail.

1. Glimepiride 0.5 mg

Glimepiride is a second-generation sulfonylurea used to lower blood sugar levels in individuals with Type 2 diabetes. It works by stimulating the pancreas to release more insulin and by making the body more sensitive to the insulin it produces. This action helps lower blood sugar levels and can also aid in better utilization of glucose in the body.

• Mechanism of Action: Glimepiride stimulates insulin secretion by binding to sulfonylurea receptors in the pancreas, thereby improving insulin release in response to blood glucose.
• Dosage: 0.5 mg of Glimepiride is typically effective for patients with mild to moderate diabetes, but the dose can be adjusted according to the patient’s response.

2. Voglibose 0.2 mg

Voglibose is an alpha-glucosidase inhibitor that works by delaying the digestion and absorption of carbohydrates in the small intestine. By slowing down the breakdown of starches and sugars, it prevents blood sugar spikes that typically occur after meals.

• Mechanism of Action: Voglibose inhibits enzymes that break down complex carbohydrates into simpler sugars, which in turn reduces the rate at which glucose enters the bloodstream. This helps manage post-meal blood sugar levels.
• Dosage: The 0.2 mg dose of Voglibose in GLIMITERIS TRIO helps prevent hyperglycemia after meals by slowing down carbohydrate absorption.

3. Metformin Hydrochloride (SR) 500 mg

Metformin Hydrochloride (SR) is a biguanide and one of the most widely prescribed medications for Type 2 diabetes. It works primarily by reducing glucose production in the liver, increasing insulin sensitivity, and improving glucose uptake by muscles. The SR (Sustained Release) formulation allows for prolonged action, reducing the frequency of doses while maintaining consistent blood sugar control throughout the day.

• Mechanism of Action: Metformin inhibits hepatic glucose production and enhances insulin sensitivity, allowing for more efficient utilization of glucose in the bloodstream.
• Dosage: 500 mg of Metformin (SR) in GLIMITERIS TRIO ensures controlled release throughout the day, helping to maintain optimal blood sugar levels with fewer side effects.

How Does GLIMITERIS TRIO 0.5/0.2/500 Work?

The combination of Glimepiride, Voglibose, and Metformin Hydrochloride (SR) in GLIMITERIS TRIO works synergistically to control blood glucose levels in individuals with Type 2 diabetes. Here's how each component contributes to diabetes management:

• Glimepiride (0.5 mg): Increases insulin secretion, which helps to lower blood sugar levels.
• Voglibose (0.2 mg): Prevents post-meal blood sugar spikes by slowing the absorption of carbohydrates in the intestines.
• Metformin Hydrochloride (SR 500 mg): Reduces the liver’s glucose production and increases the body’s sensitivity to insulin, ensuring that blood sugar levels are kept in check throughout the day.

This combination approach provides comprehensive glycemic control, addressing different pathways involved in glucose metabolism.

Uses of GLIMITERIS TRIO 0.5/0.2/500

GLIMITERIS TRIO is primarily prescribed to manage Type 2 diabetes mellitus, particularly in patients who have not achieved optimal blood glucose control with dietary changes and exercise alone. It is used when a combination of medications is required to improve glycemic control.

Key benefits of GLIMITERIS TRIO include:

• Blood Sugar Regulation: Helps lower both fasting and postprandial (after meal) blood sugar levels.
• Prevention of Complications: Proper blood sugar control can help prevent the long-term complications of diabetes, such as nerve damage, kidney issues, and heart disease.
• Convenience: The combination of three medications in a single tablet improves patient adherence to treatment by reducing the number of pills needed.

Dosage and Administration of GLIMITERIS TRIO 0.5/0.2/500

The typical dosage for GLIMITERIS TRIO is one tablet per day. However, the exact dose will depend on the patient's blood glucose levels, their response to the medication, and the advice of their healthcare provider. The tablet should be taken with meals to reduce the risk of side effects such as gastrointestinal upset.

Recommended Dosage Schedule:

• Adults: 1 tablet of GLIMITERIS TRIO 0.5/0.2/500 daily, preferably with a meal to minimize gastrointestinal discomfort.
• Adjustments: The dose may be increased or decreased based on the patient's blood sugar levels, tolerance, and overall health.

Side Effects of GLIMITERIS TRIO 0.5/0.2/500

Like all medications, GLIMITERIS TRIO can cause side effects, though not everyone will experience them. The side effects may vary depending on the individual’s sensitivity to the drug components. Common side effects include:

1. Glimepiride (0.5 mg):

• Hypoglycemia: Low blood sugar is the most common side effect of sulfonylureas like Glimepiride. Symptoms include shaking, sweating, dizziness, and confusion.
• Weight gain: Some people may experience weight gain as Glimepiride increases insulin levels.

2. Voglibose (0.2 mg):

• Gastrointestinal issues: Voglibose may cause gas, bloating, or diarrhea due to its action on the intestines.
• Abdominal discomfort: Some patients may experience mild abdominal discomfort as their digestive system adjusts to the medication.

3. Metformin Hydrochloride (SR 500 mg):

• Gastrointestinal upset: This includes nausea, vomiting, and diarrhea. These symptoms are usually temporary and improve with time.
• Lactic acidosis: Although rare, a serious side effect of Metformin is lactic acidosis, which requires immediate medical attention.
• Vitamin B12 deficiency: Prolonged use of Metformin can sometimes lead to low vitamin B12 levels.

Precautions

Before starting GLIMITERIS TRIO, it’s important to inform your healthcare provider of any medical conditions, particularly if you have:

• Kidney or liver problems
• Heart disease
• History of lactic acidosis
• Alcohol consumption
• Allergies to any components of the tablet

Additionally, pregnant and breastfeeding women should consult their doctor before taking GLIMITERIS TRIO, as it may not be suitable for these groups.

Price of GLIMITERIS TRIO 0.5/0.2/500

The cost of GLIMITERIS TRIO 0.5/0.2/500 tablets can vary depending on the location, pharmacy, and insurance coverage. Generally, the price is affordable in most regions, especially compared to the cost of purchasing multiple single medications. In India, the price for a 10-tablet pack typically ranges from INR 150 to 300, though it’s best to check with local pharmacies for the most accurate pricing.

Conclusion

GLIMITERIS TRIO 0.5/0.2/500 is an effective and convenient treatment for managing Type 2 diabetes. By combining Glimepiride 0.5 mg, Voglibose 0.2 mg, and Metformin Hydrochloride (SR) 500 mg, this medication offers a well-rounded approach to controlling blood sugar levels, preventing complications, and improving the quality of life for patients with diabetes. While GLIMITERIS TRIO can be very effective, it’s important to follow your healthcare provider’s advice on dosage and lifestyle changes for optimal results. As with any medication, regular monitoring of blood glucose levels is essential to ensure that the treatment remains effective and that side effects are minimized. Steris Healthcare Pvt Ltd, operating as Sterispharma since its founding by expert professionals in the pharmaceutical industry in February 2018, is based in Navi Mumbai. The company is certified by WHO, GMP, and ISO, emphasizing its commitment to quality and safety. Sterispharma focuses on providing high-quality drugs at affordable prices throughout India, adhering strictly to WHO guidelines. Offering the convenience of an online pharmacy, customers can easily purchase medicines with home delivery options available. Sterispharma's mission is to supply a broad range of healthcare products to meet the diverse needs of the medical community. From advanced treatments and medications for rare conditions to essential health necessities, Sterispharma aims to serve the extensive demands of the healthcare industry. You can order medicines from Sterispharma through their websites, Sterisonline  ,  Sterisindia and Sterispharma. Their extensive product lineup includes treatments for Cardiology, Asthma, Respiratory Issues, Nasal Conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/Antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental Care, and Dermatology. 

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