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Nifedipine and Lidocaine Cream: Effective Relief for Anal Fissures and Hemorrhoids.

Jun 21, 2025

Anal fissures and hemorrhoids can cause substantial pain, discomfort, and a worse quality of life. Nifedipine with Lidocaine Cream is a strong, dual-action treatment that not only relieves pain but also promotes speedier healing. This page delves into why it's a popular topical therapy, including its uses, advantages, side effects, cost concerns, and the science behind its efficacy.

What Is Nifedipine and Lidocaine Cream?

Nifedipine and Lidocaine Cream is a specially formulated topical ointment combining two effective agents:

  • Nifedipine: A calcium channel blocker that relaxes the internal anal sphincter and improves blood flow, allowing fissures and hemorrhoids to heal.
  • Lidocaine: A local anesthetic that numbs the area immediately, reducing pain during bowel movements and ongoing discomfort.

The topical combination is often prescribed in a 0.3% nifedipine + 1.5% lidocaine base, ensuring both agents work locally for relief and repair.

Nifedipine with Lidocaine Cream Applications

This topical cream tackles several anorectal issues:

Chronic Anal Fissures: Reduces sphincter pressure, allowing tears to heal in the anus. Clinical investigations reveal up to 94.5% fissure healing after six weeks, which is much greater than other therapies.

Acute Anal Fissures: Used effectively in healing early years and preventing progression to chronic fissures 

Hemorrhoidal Symptoms: Eases anal pain and inflammation, improving circulation and comfort .

Post-Hemorrhoidectomy Pain Relief: Benefits patients recovering from surgical procedures . 

 

How It Works

Nifedipine and Lidocaine Cream acts via two mechanisms:

  1. Muscle Relaxation & Increased Blood Flow

Nifedipine reduces calcium entry in smooth muscles, relaxing the anal sphincter and increasing blood flow to damaged tissue

        2. Instant Pain Relief

Lidocaine inhibits nerve impulses locally, relieving pain and making bowel motions less unpleasant. 

 

Key Benefits

  • High Healing Rates: Up to 94.5% fissure healing in controlled trials
  • Non-Surgical Solution: Comparable effectiveness to surgery without invasive risk.
  • Fewer Systemic Side Effects: Minimal systemic absorption—more tolerable than oral drugs.
  • Rapid Relief: Pain reduction often starts after first use.
  • Dual Therapeutic Effect: Tackles both pain (via lidocaine) and healing (via nifedipine).

 

Directions for Use

Cleanse the afflicted area carefully.

Apply a little quantity using an applicator or your finger (as recommended).

Frequency: Typically used twice daily (morning/night) for four to eight weeks. 

Hygiene: Wash hands thoroughly after each application.

Consistency is Key: Apply throughout the entire recommended course—even after symptoms improve. 

 

Possible Side Effects

Though mostly well-tolerated, some patients may experience:

  • Local Reactions: Redness, stinging, swelling, itching, rash 
  • Systemic Effects: Occasionally flushing, headache, dizziness, hypotension .
  • Allergic Reactions: Rarely, severe reactions such as hives or breathing difficulties .

If side effects persist or worsen, stop treatment and consult your physician promptly.

 

Why Choose Steris Healthcare For Nifedipine and Lidocaine Cream? 

Steris Healthcare is a reputable brand in the pharmaceutical sector, providing high-quality formulations backed by innovation, compliance, and patient-centered care. When it comes to Nifedipine with Lidocaine Cream, Steris Healthcare delivers an amazing combo solution that meets the highest safety, effectiveness, and cost criteria.
Our Nifedipine with Lidocaine Cream is meticulously made in WHO-GMP-certified facilities utilizing high-quality ingredients. This dual-action topical therapy is particularly intended to give effective relief from anal fissures and hemorrhoids by combining nifedipine's muscle-relaxing properties with lidocaine's quick numbing action. Every batch goes through rigorous quality control and clinical validation to ensure consistent performance and therapeutic outcomes.

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