Introduction

What is OB-COLLAR 10?

OB-COLLAR 10 is a medication that contains Obeticholic Acid (10mg) as its active ingredient. Obeticholic Acid is a bile acid analogue and is used primarily in the treatment of liver diseases such as Primary Biliary Cholangitis (PBC). PBC is a chronic liver condition that occurs when the bile ducts in the liver become damaged and inflamed, leading to bile buildup and liver damage.

Obeticholic Acid works by acting on specific receptors in the liver, helping to reduce inflammation, increase bile flow, and reduce liver damage, making it an essential part of the therapeutic regimen for individuals suffering from PBC and other liver-related conditions. OB-COLLAR 10 provides a 10mg dose of Obeticholic Acid in a convenient tablet form, aimed at improving liver function and quality of life for individuals with chronic liver conditions.

Composition of OB-COLLAR 10

Each tablet of OB-COLLAR 10 contains:

• Obeticholic Acid (10mg): The active ingredient in OB-COLLAR 10 is Obeticholic Acid, a potent drug used to treat conditions like Primary Biliary Cholangitis (PBC). It works by activating the farnesoid X receptor (FXR) in the liver, which plays a significant role in controlling bile acid synthesis, secretion, and transport.

• Excipients: These are inactive ingredients that help in the manufacturing process of the tablet and ensure the stability, dissolution, and proper delivery of the drug. These include binders, fillers, and coatings.

Key Features of OB-COLLAR 10

1. Targeted Action on the Liver:

   • Obeticholic Acid works specifically on the liver by activating the FXR receptor, which helps regulate the metabolism of bile acids, reduce liver inflammation, and promote liver health.

2. Effective Treatment for Primary Biliary Cholangitis (PBC):

   • OB-COLLAR 10 is particularly effective for managing PBC, a chronic liver disease that leads to bile duct damage. It helps in reducing the progression of the disease, controlling symptoms, and improving overall liver function.

3. Once-Daily Dosing:

   • OB-COLLAR 10 is typically taken once daily, making it convenient for patients to adhere to their prescribed treatment regimen.

4. Improvement of Liver Function:

   • By reducing bile buildup and inflammation in the liver, OB-COLLAR 10 helps improve liver function, which is crucial for preventing further liver damage and complications such as cirrhosis or liver failure.

5. Well-Tolerated in Most Patients:

   • Most patients tolerate OB-COLLAR 10 well, with side effects being generally mild and transient. It offers a promising treatment for individuals with chronic liver conditions who require long-term management.

How OB-COLLAR 10 Works

Obeticholic Acid, the active ingredient in OB-COLLAR 10, works by activating the Farnesoid X Receptor (FXR). FXR plays a critical role in regulating bile acid levels, inflammation, and liver cell function. Here's how Obeticholic Acid acts in the body:

1. Regulates Bile Acid Synthesis and Transport:

   • FXR activation helps reduce the synthesis of bile acids, which are critical for digestion but can be toxic when accumulated in the liver in conditions like PBC. It also promotes the proper transport of bile acids, reducing the risk of liver damage.

2. Reduces Liver Inflammation:

   • By activating FXR, Obeticholic Acid has anti-inflammatory effects in the liver. This is particularly beneficial in conditions like PBC, where inflammation of the bile ducts leads to liver damage.

3. Improves Liver Fibrosis:

   • Obeticholic Acid helps to slow down the progression of fibrosis, which is the thickening and scarring of liver tissue. By improving bile flow and reducing liver inflammation, the drug can slow the progression of liver damage and prevent the development of cirrhosis.

4. Enhances Cholesterol Metabolism:

   • Obeticholic Acid can also have a positive effect on lipid metabolism, helping to lower cholesterol levels in the liver and bloodstream, which may help reduce the risk of cardiovascular issues in patients with liver disease.

Usage of OB-COLLAR 10

Indications:

• Primary Biliary Cholangitis (PBC): OB-COLLAR 10 is primarily used to treat PBC, a chronic liver disease that can lead to cirrhosis and liver failure if left untreated.

• Other Bile Acid Metabolism Disorders: It may also be used for other conditions where bile acid regulation is disrupted, though this would be determined by a healthcare provider.

Dosage:

• Standard Adult Dosage: The typical starting dose for OB-COLLAR 10 is 10mg once daily, taken with or without food. In some cases, the dose may be adjusted based on the patient's response and tolerance to the drug.

• The dose may be increased to 25mg once daily if necessary, depending on the individual's clinical condition and liver function tests.

• It is important to follow the prescribed dosage and not to adjust the dose without consulting a healthcare provider.

Administration:

• Take once daily with or without food.

• Swallow the tablet whole; do not crush or chew.

• Adhere to the dosing schedule as prescribed by your healthcare provider to ensure consistent therapeutic effects.

Benefits of OB-COLLAR 10

1. Reduces Liver Inflammation:

   • By activating FXR receptors, OB-COLLAR 10 helps reduce inflammation in the liver, which is a key factor in diseases like PBC.

2. Improves Liver Function:

   • It enhances bile flow and helps reduce bile acid buildup, improving liver function and preventing the progression of liver damage and fibrosis.

3. Prevents Disease Progression:

   • OB-COLLAR 10 can slow the progression of Primary Biliary Cholangitis (PBC) and prevent complications such as cirrhosis, liver failure, and the need for a liver transplant.

4. Convenient Once-Daily Dosing:

   • The once-daily dosage is convenient and increases patient adherence to the treatment regimen.

5. Minimal Systemic Side Effects:

   • Obeticholic Acid acts primarily on the liver, and its effects are largely localized, meaning that systemic side effects are generally mild and infrequent.

Side Effects of OB-COLLAR 10

While OB-COLLAR 10 is generally well-tolerated, some side effects may occur. These include:

Common Side Effects:

• Fatigue

• Abdominal pain or discomfort

• Itching (pruritus), especially in individuals with liver disease

• Nausea or mild gastrointestinal upset

Serious Side Effects (Rare):

• Liver problems: Symptoms may include yellowing of the skin or eyes (jaundice), dark urine, or severe abdominal pain. If any of these symptoms occur, immediate medical attention is required.

• Cholesterol problems: Rarely, Obeticholic Acid can cause elevated cholesterol levels or impact lipid metabolism, leading to increased risk of cardiovascular issues.

• Severe fatigue or weakness: Persistent tiredness could indicate a more serious underlying problem and should be discussed with a doctor.

Patients should have regular liver function tests to monitor for any adverse effects during treatment.

FAQ Section

1. What is OB-COLLAR 10 used for?

OB-COLLAR 10 is primarily used to treat Primary Biliary Cholangitis (PBC), a chronic liver disease that causes inflammation and damage to the bile ducts. It is also used in the management of other liver conditions associated with bile acid metabolism disorders.

2. How does OB-COLLAR 10 work?

OB-COLLAR 10 contains Obeticholic Acid, which activates the FXR receptor in the liver. This action helps reduce liver inflammation, regulate bile acid production, and improve bile flow, leading to better liver function and reduced liver damage.

3. How should I take OB-COLLAR 10?

Take OB-COLLAR 10 as prescribed by your healthcare provider. The typical dose is 10mg once daily, which can be increased if necessary. It can be taken with or without food. Swallow the tablet whole without crushing or chewing.

4. Are there any side effects of OB-COLLAR 10?

Common side effects include fatigue, abdominal discomfort, and nausea. Serious side effects, though rare, include liver problems, cholesterol changes, and severe fatigue. Regular liver function tests are recommended during treatment.

5. Can OB-COLLAR 10 be used in patients with cirrhosis?

Patients with advanced liver disease, such as cirrhosis, should use OB-COLLAR 10 with caution and under close medical supervision. A healthcare provider will determine if the medication is appropriate based on the individual’s liver function.

Conclusion

OB-COLLAR 10 is an effective treatment for Primary Biliary Cholangitis (PBC) and other liver conditions involving disrupted bile acid metabolism. By activating the FXR receptor, Obeticholic Acid helps reduce liver inflammation, improve bile flow, and slow the progression of liver damage. The once-daily dosage makes it convenient for patients, and with proper monitoring, it can significantly improve liver function and prevent complications such as cirrhosis or liver failure. 

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

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