Introduction

What is MESALMILE OD?

MESALMILE OD is an extended-release formulation of Mesalamine (1200mg), a medication used primarily in the management of inflammatory bowel diseases (IBD) such as Ulcerative Colitis and Crohn’s Disease. Mesalamine, also known as 5-aminosalicylic acid (5-ASA), is an anti-inflammatory agent that works directly on the lining of the intestines to reduce inflammation and control the symptoms associated with these conditions. The OD in MESALMILE OD stands for Once Daily, indicating that this formulation is designed to be taken once a day for convenience and consistent symptom control.

Mesalamine’s primary action is to reduce inflammation, swelling, and ulceration in the intestinal tract, which is crucial for managing IBD and improving the quality of life for individuals suffering from these chronic conditions.

Composition of MESALMILE OD

Each tablet of MESALMILE OD contains:

• Mesalamine (1200mg): The active ingredient, Mesalamine, is a 5-aminosalicylic acid (5-ASA) compound that works locally in the intestines to reduce inflammation and prevent flare-ups in conditions like Ulcerative Colitis and Crohn’s Disease.

• Excipients: These are inactive ingredients used to make the tablet stable, ensure proper drug release, and facilitate easier ingestion. Excipients may include binders, fillers, and coatings, but they do not contribute directly to the therapeutic effect.

Key Features of MESALMILE OD

1. Extended-Release Formulation:

   • The extended-release design of MESALMILE OD allows for the gradual release of Mesalamine throughout the day, ensuring a consistent therapeutic effect and minimizing fluctuations in drug concentration.

2. Once-Daily Dosing:

   • This formulation is designed for once-daily administration, improving compliance and convenience for patients, making it easier to stick to the prescribed treatment regimen.

3. Targeted Action:

   • Mesalamine works specifically on the intestinal mucosa (lining of the intestines), where it helps to reduce inflammation, control flare-ups, and prevent further tissue damage from conditions like Ulcerative Colitis.

4. Proven Efficacy:

   • Mesalamine has a long track record of efficacy in managing inflammatory bowel diseases and is considered a first-line therapy for mild to moderate Ulcerative Colitis. It is effective in inducing and maintaining remission.

5. Minimal Systemic Absorption:

   • Mesalamine primarily works locally in the intestines and is minimally absorbed into the bloodstream, which reduces the risk of systemic side effects commonly associated with other types of medication used to treat IBD.

How MESALMILE OD Works

MESALMILE OD contains Mesalamine, which acts by inhibiting the production of certain pro-inflammatory molecules in the intestine, such as prostaglandins and leukotrienes. These molecules are involved in the inflammatory response and contribute to the pain, swelling, and ulceration seen in conditions like Ulcerative Colitis and Crohn's Disease.

The extended-release formulation ensures that Mesalamine is slowly released into the intestines over a prolonged period, maximizing its therapeutic effect and improving the control of symptoms. This controlled release also helps maintain stable drug levels in the bloodstream and the intestinal mucosa, which is essential for managing the chronic and relapsing nature of IBD.

The mechanism of action of Mesalamine specifically includes:

1. Inhibition of Inflammatory Mediators: Mesalamine blocks the cyclooxygenase (COX) enzyme, reducing the production of prostaglandins, which are chemicals that promote inflammation and pain.

2. Inhibition of Free Radical Production: It also reduces the production of reactive oxygen species (ROS) and other free radicals, which contribute to cellular damage and inflammation.

3. Immunosuppressive Effects: Mesalamine can modulate immune system activity in the intestines, reducing the inflammatory response.

Usage of MESALMILE OD

MESALMILE OD is primarily prescribed for the management of inflammatory bowel diseases (IBD), including:

• Ulcerative Colitis: A chronic condition that causes inflammation and ulcers in the colon and rectum. MESALMILE OD is used to induce remission during flare-ups and to maintain remission once the disease is under control.

• Crohn’s Disease: Though Crohn's Disease can affect any part of the gastrointestinal tract, Mesalamine can be effective in treating small intestine and colonic involvement. It is used to help manage inflammation and prevent flare-ups.

• Proctitis: A condition characterized by inflammation of the rectum. Mesalamine can help alleviate symptoms and manage flare-ups.

Dosage:

The standard adult dose of MESALMILE OD is:

• 1 tablet (1200mg) once daily, preferably taken with food to enhance absorption and minimize gastrointestinal discomfort.

• The dose may vary based on the severity of the condition and the healthcare provider's instructions.

Instructions for Use:

• Swallow the tablet whole: Do not chew or crush the tablet, as it is designed for extended-release action.

• Take with a full glass of water to help the tablet dissolve and ensure proper absorption.

• Consistency is key: Take MESALMILE OD at the same time each day to help remember your dose and maintain stable blood levels.

Benefits of MESALMILE OD

1. Efficacy in Managing Inflammatory Bowel Diseases:

   • MESALMILE OD is highly effective in managing symptoms of Ulcerative Colitis and Crohn's Disease, helping to reduce inflammation, control flare-ups, and maintain remission.

2. Convenient Once-Daily Dosing:

   • The once-daily dosage makes it easier for patients to incorporate the medication into their daily routine, improving patient adherence to the treatment regimen.

3. Reduced Risk of Systemic Side Effects:

   • Since Mesalamine works primarily in the intestines and has minimal systemic absorption, the risk of systemic side effects (like liver damage or kidney issues) is significantly reduced.

4. Long-Term Management:

   • MESALMILE OD is suitable for long-term use in the management of chronic conditions like Ulcerative Colitis and Crohn’s Disease, offering sustained symptom control over time.

5. Targeted Action at the Site of Inflammation:

   • Mesalamine works directly at the site of inflammation in the intestines, making it a highly targeted treatment for IBD, with fewer off-target effects.

Side Effects of MESALMILE OD

As with all medications, MESALMILE OD can cause side effects, although not everyone will experience them. Some of the common and serious side effects include:

Common Side Effects:

• Headache

• Abdominal discomfort or cramps

• Diarrhea or gas

• Nausea or vomiting

• Fatigue

Serious Side Effects (Rare):

• Severe allergic reactions (rash, itching, swelling, difficulty breathing)

• Kidney problems: Signs include changes in urination, swelling, or unexplained fatigue.

• Liver issues: Symptoms may include yellowing of the skin or eyes (jaundice), dark urine, or persistent nausea.

If you experience any of these serious side effects, seek medical attention immediately.

FAQ Section

1. What is MESALMILE OD used for?

MESALMILE OD is used to treat Ulcerative Colitis, Crohn’s Disease, and other conditions involving inflammation in the intestines. It helps to reduce intestinal inflammation, control flare-ups, and maintain remission.

2. How should I take MESALMILE OD?

Take 1 tablet (1200mg) of MESALMILE OD once daily, preferably with food. Swallow the tablet whole with a full glass of water. Do not chew or crush the tablet.

3. Can I take MESALMILE OD with other medications?

Before using MESALMILE OD with other medications, consult your healthcare provider. Some drugs, particularly antacids, blood thinners, or immunosuppressive drugs, may interact with Mesalamine.

4. Can MESALMILE OD cause side effects?

Yes, MESALMILE OD may cause side effects like headache, abdominal discomfort, or diarrhea. Rarely, it can lead to serious side effects such as kidney or liver issues. If you experience severe side effects, seek medical attention immediately.

5. How long does it take for MESALMILE OD to work?

It may take several weeks for MESALMILE OD to show full therapeutic benefits. Most patients experience symptom relief within a few days to weeks, but long-term use is often necessary for maintaining remission in chronic conditions like Ulcerative Colitis.

Conclusion

MESALMILE OD is an effective and convenient treatment for managing Ulcerative Colitis, Crohn’s Disease, and other forms of inflammatory bowel disease (IBD). The extended-release formulation of Mesalamine allows for once-daily dosing, offering convenience and consistent symptom control. By targeting the intestines, MESALMILE OD reduces inflammation and helps prevent flare-ups, significantly improving the quality of life for individuals with chronic digestive conditions. 

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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