Introduction

What is MESALMILE 400?

MESALMILE 400 is a medication containing Mesalamine (400mg), designed for the treatment of inflammatory bowel diseases (IBD) such as Ulcerative Colitis and Crohn's disease. Mesalamine is a type of 5-aminosalicylic acid (5-ASA) drug that works by reducing inflammation in the digestive tract. The extended-release (ER) formulation of MESALMILE 400 allows for the gradual release of the active ingredient, providing sustained therapeutic effects over an extended period, improving patient compliance.

MESALMILE 400 is typically used to manage flare-ups of IBD, as well as to maintain remission in patients who are in recovery. It works by targeting the inflammation in the intestines and reducing it, which helps in relieving symptoms like diarrhea, abdominal pain, and rectal bleeding.

Composition of MESALMILE 400

• Active Ingredient: Mesalamine (400mg)

  • Mesalamine (also known as 5-aminosalicylic acid or 5-ASA) is the active ingredient in MESALMILE 400. It works directly on the lining of the intestines to decrease inflammation by inhibiting the production of chemicals that cause inflammation in the digestive tract.

• Excipients:

  • These are inactive ingredients used in the formulation of the tablet to provide stability, help with the controlled release of Mesalamine, and ensure ease of use.

Extended-release formulation (ER):

• The extended-release formulation of MESALMILE 400 allows the medication to be released slowly into the body, providing a longer-lasting effect and reducing the need for frequent dosing.

Key Features of MESALMILE 400

1. Effective Inflammatory Bowel Disease Management:

   • MESALMILE 400 helps reduce the inflammation that occurs in the intestines due to conditions like Ulcerative Colitis and Crohn's disease, providing relief from symptoms such as diarrhea, abdominal cramping, rectal bleeding, and fever.

2. Extended-Release Formulation:

   • The extended-release nature of the tablet ensures that Mesalamine is gradually released over time, providing a prolonged therapeutic effect and reducing the need for multiple daily doses.

3. Targeted Action:

   • Mesalamine is a topical treatment that works directly where inflammation occurs— in the lining of the intestines. It specifically targets the affected areas, thus minimizing systemic side effects.

4. Minimal Systemic Absorption:

   • MESALMILE 400 acts primarily on the intestines and is minimally absorbed into the bloodstream, reducing the risk of side effects associated with systemic medications.

5. Convenient Dosing:

   • MESALMILE 400 is typically taken once or twice daily, depending on the condition being treated, which makes it easy to incorporate into a patient’s daily routine.

How MESALMILE 400 Works

Mesalamine (the active ingredient in MESALMILE 400) is an anti-inflammatory agent that works primarily by inhibiting the production of inflammatory chemicals (prostaglandins and leukotrienes) in the gastrointestinal tract. It also acts as an immunosuppressive agent, reducing the activity of the immune system in the intestines and thereby decreasing inflammation and damage to the lining of the digestive tract.

The extended-release formulation of MESALMILE 400 allows it to be released gradually in the intestines, providing longer-lasting relief. By delivering the medication over an extended period, it helps control the symptoms of IBD, including inflammation, cramping, and irregular bowel movements.

The exact mechanism of action is still not fully understood, but it is believed that Mesalamine works by:

• Inhibiting cyclooxygenase (COX) enzymes, which are involved in the production of inflammatory prostaglandins.

• Blocking the production of leukotrienes, substances that contribute to inflammation.

• Reducing free radical production and inflammation in the intestinal wall.

By acting locally on the intestinal lining, MESALMILE 400 helps maintain remission and prevent future flare-ups of IBD.

Usage of MESALMILE 400

MESALMILE 400 is used to treat inflammatory bowel diseases (IBD), such as:

• Ulcerative Colitis: An inflammatory condition that primarily affects the colon and rectum, causing symptoms like diarrhea, abdominal cramps, blood in stools, and weight loss.

• Crohn's Disease: A form of IBD that can affect any part of the gastrointestinal tract, leading to symptoms like chronic diarrhea, abdominal pain, weight loss, and fatigue.

It is also used in the maintenance of remission in patients who have achieved improvement in their symptoms and need ongoing therapy to prevent flare-ups.

Dosage:

• Adults: The typical dose is 1 tablet (400mg) once or twice daily, depending on the severity of the disease and the doctor's recommendations.

• Children: The use of MESALMILE 400 in children should be under the guidance of a healthcare provider, as dosing may vary.

Instructions for Use:

• Take MESALMILE 400 with food or as directed by your healthcare provider.

• Swallow the tablet whole; do not crush, chew, or break it, as this may interfere with the release mechanism.

• It is usually recommended to take the medication at the same time each day to help remember the dosing schedule.

• Do not exceed the prescribed dosage.

Benefits of MESALMILE 400

1. Reduces Inflammation:

   • MESALMILE 400 is highly effective at reducing the inflammation in the intestines caused by Ulcerative Colitis and Crohn's disease, which helps relieve symptoms such as abdominal pain, diarrhea, and rectal bleeding.

2. Maintains Remission:

   • It plays an important role in maintaining remission, reducing the likelihood of flare-ups in patients who have experienced improvement in their symptoms.

3. Convenient Dosing with Extended-Release Formulation:

   • The extended-release formulation allows for fewer doses per day, improving patient adherence and convenience.

4. Minimal Side Effects:

   • Since Mesalamine works locally in the intestines, it has a lower likelihood of causing systemic side effects compared to other treatments for IBD.

5. Safe for Long-term Use:

   • Mesalamine can be used for long-term management of IBD without the severe side effects often associated with corticosteroids or immunosuppressive drugs.

6. Well-Tolerated:

   • MESALMILE 400 is generally well-tolerated, with minimal gastrointestinal irritation compared to other treatments for IBD.

Side Effects of MESALMILE 400

While MESALMILE 400 is generally well-tolerated, it can cause side effects in some individuals. These may include:

• Common side effects:

  • Abdominal discomfort or bloating.

  • Nausea or vomiting.

  • Headache.

  • Diarrhea or constipation.

• Serious side effects (rare):

  • Severe allergic reactions, including rash, itching, or swelling (especially in the face/tongue/throat).

  • Blood in stools or signs of gastrointestinal bleeding.

  • Liver problems, such as yellowing of the skin or eyes, dark urine, or severe fatigue.

  • Kidney issues, including changes in urine output.

If any of the above symptoms occur, it is important to seek immediate medical attention.

FAQ Section

1. What is MESALMILE 400 used for?

MESALMILE 400 is used to treat inflammatory bowel diseases (IBD), including Ulcerative Colitis and Crohn's disease. It reduces inflammation in the intestines and helps manage flare-ups of the disease.

2. How does MESALMILE 400 work?

MESALMILE 400 works by reducing inflammation in the intestines. It inhibits the production of inflammatory chemicals and works directly on the intestinal lining to alleviate symptoms such as diarrhea, pain, and bleeding.

3. Can I take MESALMILE 400 with other medications?

Always consult your healthcare provider before taking MESALMILE 400 with other medications, especially those used to treat IBD, as there may be interactions. It's also important to inform your doctor if you're taking medications for liver or kidney issues.

4. How long does it take for MESALMILE 400 to work?

MESALMILE 400 usually begins to work within a few days to weeks, depending on the severity of the condition. It is important to continue taking it regularly as prescribed to maintain remission.

5. Are there any side effects of MESALMILE 400?

Some common side effects of MESALMILE 400 include abdominal discomfort, nausea, and headache. Rarely, it can cause more serious effects, such as liver issues or severe allergic reactions.

Conclusion

MESALMILE 400 is a highly effective extended-release formulation of Mesalamine (400mg) used to manage inflammatory bowel diseases such as Ulcerative Colitis and Crohn's disease. By reducing inflammation in the intestines, MESALMILE 400 helps alleviate symptoms like abdominal pain, diarrhea, and rectal bleeding, while also helping maintain remission in IBD patients. 

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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