IVADINE CR 10 is a prescription cardiovascular drug used to treat stable angina pectoris and some forms of heart failure. It contains 10 mg of Ivabradine Controlled Release. Ivabradine is a selective If (funny current) channel inhibitor that lowers heart rate in the heart's sinoatrial node without changing blood pressure or myocardial contractility.

In individuals with chronic heart failure and coronary artery disease (CAD), elevated heart rate is a major factor in ischemic events. IVADINE CR 10 increases exercise tolerance, decreases heart rate, and lowers myocardial oxygen demand in individuals who are at risk for angina or left ventricular failure by specifically targeting the pacemaker current.

The controlled-release formulation ensures prolonged therapeutic effect with once-daily dosing, enhancing patient compliance and providing stable heart rate control throughout the day.

Uses

IVADINE CR 10 is primarily indicated for cardiovascular conditions related to elevated heart rate and myocardial ischemia:

1. Stable Angina Pectoris

IVADINE CR 10 is used for the long-term management of chronic stable angina in patients who are in sinus rhythm and whose heart rate is elevated, helping to reduce the frequency and severity of angina attacks.

2. Heart Failure

In patients with chronic heart failure (NYHA Class II-III) and left ventricular systolic dysfunction, Ivabradine can be used as adjunct therapy to reduce heart rate and improve symptoms, particularly in those already on guideline-directed therapy including beta-blockers.

3. Heart Rate Control

For patients with persistent tachycardia or elevated resting heart rate, IVADINE CR 10 helps maintain optimal cardiac rhythm without compromising blood pressure.

4. Combination Therapy

It can be used alongside beta-blockers, ACE inhibitors, or diuretics where additional heart rate control is needed for symptomatic relief or improved cardiovascular outcomes.

Benefits

IVADINE CR 10 offers several clinical and patient-centric advantages over traditional therapies:

1. Selective Heart Rate Reduction

By targeting the If channels in the sinoatrial node, Ivabradine reduces heart rate without affecting blood pressure or myocardial contractility, minimizing adverse hemodynamic effects.

2. Improved Exercise Tolerance

Lowering heart rate decreases myocardial oxygen consumption, allowing patients to perform physical activities with fewer episodes of angina.

3. Once-Daily Controlled Release

The controlled-release formulation ensures stable plasma levels throughout the day, enhancing therapeutic efficacy and simplifying dosing schedules.

4. Symptom Relief

IVADINE CR 10 reduces the frequency and severity of angina attacks, improving quality of life and enabling better daily functioning.

5. Complementary Therapy

The drug can be safely combined with other standard therapies for heart failure or angina, providing comprehensive cardiovascular management.

6. Well-Tolerated

IVADINE CR 10 has a favorable safety profile with minimal impact on blood pressure, metabolic parameters, or ventricular function, making it suitable for long-term therapy.

Dosage

The dosage of IVADINE CR 10 should be individualized according to the patient’s clinical condition and heart rate response.

Recommended Dosage:

• Usual Adult Dose: One tablet (10 mg) once daily

• Route: Oral

• Administration: Swallow tablets whole with water; can be taken with or without food

Important Dosage Considerations:

• Dose may be adjusted based on heart rate and tolerance; typical range: 5–10 mg once daily

• Not recommended for patients with resting heart rate below 60 bpm before starting therapy

• Gradual dose adjustments should be made under medical supervision

Regular monitoring of heart rate, blood pressure, and ECG is recommended to ensure optimal therapy and minimize side effects.

Side Effects

IVADINE CR 10 is generally well tolerated, though some patients may experience side effects:

Common Side Effects:

• Visual disturbances such as transient phosphenes (seeing bright spots or flashes)

• Headache

• Dizziness or mild fatigue

• Bradycardia (slow heart rate)

Less Common Side Effects:

• Nausea or gastrointestinal discomfort

• Palpitations or irregular heartbeat

• Mild hypotension

Rare but Serious Side Effects:

• Severe bradycardia or heart block

• Worsening heart failure symptoms in susceptible patients

• Severe allergic reactions such as rash or swelling

Patients experiencing persistent, severe, or unusual side effects should contact their healthcare provider immediately.

Precautions and Warning

Certain precautions must be observed for safe use of IVADINE CR 10:

1. Heart Conditions

Use with caution in patients with sinoatrial block, sick sinus syndrome, or severe heart failure. Ivabradine is contraindicated in patients with atrial fibrillation or other non-sinus rhythms.

2. Blood Pressure Monitoring

Although Ivabradine primarily lowers heart rate, blood pressure should still be monitored in patients at risk of hypotension.

3. Liver Impairment

Dose adjustments may be required in patients with moderate to severe hepatic impairment.

4. Pregnancy and Lactation

IVADINE CR 10 should be used during pregnancy or breastfeeding only if clearly indicated by a physician.

5. Drug Interactions

Patients should inform their healthcare provider if taking:

• Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)

• Other heart rate-lowering drugs (beta-blockers, calcium channel blockers)

• Antiarrhythmic medications

6. Lifestyle Measures

For optimal management of angina or heart failure, therapy should be combined with healthy diet, regular exercise, limited salt intake, and avoidance of smoking or alcohol excess.

Conclusion

IVADINE CR 10, containing Ivabradine Controlled Release 10 mg, is a highly effective and clinically proven therapy for the long-term management of stable angina and heart rate control in selected heart failure patients. Its selective If channel inhibition provides precise heart rate reduction without compromising blood pressure or myocardial function, offering symptomatic relief and improved exercise tolerance.

The once-daily controlled-release formulation ensures consistent plasma levels, enhancing patient adherence and reducing the frequency of angina attacks. With a favorable safety and tolerability profile, IVADINE CR 10 is suitable for chronic therapy in adults with sinus rhythm, elevated resting heart rate, or persistent angina