Introduction

Alcohol dependence is a complex medical and social problem that affects millions worldwide. Long-term alcohol use alters the brain’s chemical balance, leading to cravings, withdrawal symptoms, and high chances of relapse. While detoxification helps in initial recovery, sustaining abstinence is often the most difficult challenge.Here, ACAMPURE 333 (Acamprosate Calcium Tablets 333 mg) plays a crucial role. It is a clinically proven anti-craving medication that supports rehabilitation by reducing the urge to drink and restoring brain chemistry disrupted by alcohol abuse. When combined with counseling and psychosocial therapy, Acamprosate significantly improves the chances of long-term recovery.

What is Acamprosate Calcium?

Acamprosate is a centrally acting anti-craving agent used in the treatment of alcohol dependence. It works by restoring the balance between excitatory (glutamate) and inhibitory (GABA) neurotransmitters in the brain, which gets disrupted by long-term alcohol use.

Composition

Each ACAMPURE 333 tablet contains:

• Acamprosate Calcium 333 mg (Gastro-resistant tablet)

Excipients: Pharmaceutical-grade binders, fillers, and stabilizers to ensure maximum bioavailability and patient safety.

How Does Acamprosate Work? (Mechanism of Action)

• Chronic alcohol consumption increases glutamate (excitatory neurotransmitter) and decreases GABA (inhibitory neurotransmitter), creating chemical imbalance in the brain.

• When alcohol is stopped, this imbalance triggers cravings, anxiety, and withdrawal discomfort.

• Acamprosate restores balance by:

  • Reducing excess glutamate activity (over-excitation).

  • Enhancing GABAergic calming activity.

• The result: Cravings reduce, withdrawal anxiety lessens, and the brain adapts better to life without alcohol.

Clinical Benefits of ACAMPURE 333

1. Supports Abstinence – Proven to increase the number of alcohol-free days.

2. Reduces Cravings – Makes it easier to resist triggers.

3. Non-addictive – No risk of dependence, unlike some psychiatric drugs.

4. Safe in Liver Disease – Can be used in patients with mild to moderate liver problems.

5. Improves Quality of Life – Helps patients focus on work, family, and health without alcohol interference.

6. Works with Therapy – Best results seen when combined with counseling, group therapy, or rehab programs.

Uses of ACAMPURE 333 (Acamprosate 333 mg Tablets)

• Alcohol dependence management

• Prevention of relapse after detoxification

• Reduction of alcohol craving

• Maintenance of abstinence

• Adjunct to psychosocial and behavioral therapy

Dosage and Administration

• Standard adult dose: 666 mg (2 tablets of 333 mg) three times daily.

• Elderly or patients <60 kg: Dose adjustment may be required.

• Mode of administration: Take with water, after meals, swallow whole (do not crush).

• Duration of therapy: Typically 6–12 months, or longer as advised.

 Important: Treatment should start immediately after alcohol detoxification and continue even if the patient relapses temporarily.

Side Effects

Though generally well tolerated, some patients may experience:

• Gastrointestinal: Diarrhea, abdominal cramps, nausea.

• Nervous system: Insomnia, anxiety, dizziness, headache.

• Skin: Rash, itching (rare).

• Others: Muscle weakness, fatigue.

Most side effects are mild and temporary.

Precautions and Warnings

• Pregnancy & Breastfeeding: Use only under medical advice.

• Severe Renal Impairment: Contraindicated.

• Age restrictions: Not recommended for patients <18 years.

• Compliance is key: Missing doses reduces effectiveness.

• Not for detox: Does not treat acute withdrawal symptoms, only helps maintain abstinence.

Drug Interactions

• Acamprosate is excreted unchanged via kidneys, so interactions are minimal.

• Safe to use with disulfiram or naltrexone in combined therapy.

• Should not be combined with alcohol, as it reduces efficacy.

Lifestyle and Patient Advice

• Stay active with exercise and hobbies to reduce cravings.

• Join support groups or counseling sessions for motivation.

• Avoid social triggers like bars, parties with alcohol.

• Maintain a healthy diet and hydration to support recovery.

• Take medicine regularly without skipping doses.

Why Buy ACAMPURE 333 from Steris Healthcare Pvt Ltd?

Steris Healthcare is a reliable and ethical pharmaceutical brand trusted across India for its:

• WHO-GMP certified facilities ensuring global standards.

• High-quality formulations tested for safety and efficacy.

• Affordable pricing to support patients from all backgrounds.

• Wide product availability across hospitals, clinics, and pharmacies.

• Customer-centric approach focused on patient well-being.

By choosing Steris Healthcare’s ACAMPURE 333, you ensure superior quality, clinically effective treatment, and long-term trust.

FAQs on Acamprosate Calcium 333 mg (ACAMPURE 333)

Q1. Is Acamprosate habit-forming?
No, it is non-addictive and safe for long-term use.

Q2. How soon does Acamprosate start working?
Effects usually appear after 5–7 days, with maximum benefits seen after a few weeks.

Q3. Can Acamprosate be taken with food?
Yes, it should be taken after meals for best absorption.

Q4. Does it cure alcoholism completely?
No, it is not a cure. It helps maintain abstinence when combined with therapy and willpower.

Q5. What if I miss a dose?
Take the missed dose as soon as possible, but skip it if it’s almost time for the next dose. Do not double dose.

Q6. Can I drink alcohol while taking Acamprosate?
No, alcohol reduces the medicine’s effect and increases relapse risk.

Q7. Is Acamprosate safe for patients with liver disease?
Yes, unlike many other anti-craving drugs, it is safe in mild to moderate liver impairment.

Q8. Can Acamprosate be stopped suddenly?
Yes, it can be discontinued without withdrawal symptoms, but always consult your doctor first.

Conclusion

ACAMPURE 333 (Acamprosate Calcium Tablets 333 mg) is a clinically proven therapy for reducing alcohol cravings and maintaining abstinence. With its non-addictive nature, safety in liver disease, and proven efficacy, it is an essential part of alcohol dependence treatment programs.When you choose Steris Healthcare Pvt Ltd, you are guaranteed high-quality, affordable, and effective medicines backed by trust and expertise.