Introduction

ZOLMIGRAN is a sterile intravenous infusion containing Zoledronic Acid 5 mg in 100 ml solution, used primarily to treat bone-related complications caused by cancer and osteoporosis. Zoledronic acid belongs to the bisphosphonate class of drugs and is known for its potent inhibition of bone resorption.It is administered once yearly or as required, making it a convenient and effective treatment option for managing several bone conditions.

Zoledronic Acid Injection Uses

ZOLMIGRAN is indicated for the treatment of:

• Osteoporosis in postmenopausal women

• Osteoporosis in men

• Prevention of fractures after hip fractures

• Paget’s disease of bone

• Hypercalcemia of malignancy

• Bone metastases due to solid tumors

• Multiple myeloma-related bone damage

Mechanism of Action

Zoledronic acid inhibits osteoclast-mediated bone resorption by binding to the bone mineral matrix. It suppresses the activity and recruitment of osteoclasts (cells responsible for bone breakdown), reducing bone turnover. This leads to increased bone mineral density and reduced fracture risk, especially in osteoporosis patients.In cancer patients, it helps manage skeletal-related events (SREs) such as pathological fractures and spinal cord compression.

Dosage and Administration

ZOLMIGRAN (Zoledronic Acid Injection 5mg/100ml) is administered intravenously over no less than 15 minutes, once a year for osteoporosis or as per the schedule for oncological indications.

Typical Dosage:

Note: Adequate hydration and calcium/vitamin D supplementation are necessary during therapy.

Zoledronic Acid Injection Side Effects

Like all medicines, ZOLMIGRAN may cause side effects. Common and rare effects include:

Common Side Effects:

• Fever or flu-like symptoms (within 1–3 days)

• Bone, joint, or muscle pain

• Fatigue

• Headache

• Nausea or vomiting

Less Common / Serious Side Effects:

• Hypocalcemia (low calcium levels)

• Renal impairment

• Osteonecrosis of the jaw (ONJ)

• Atypical femur fractures (rare)

• Allergic reactions (rash, swelling, itching)

Always monitor renal function before each dose. Report persistent pain, dental issues, or any severe reactions to a doctor immediately.

Precautions and Warnings

• Not recommended in severe renal impairment (Creatinine clearance < 35 mL/min)

• Ensure adequate hydration before and after infusion

• Correct vitamin D and calcium deficiency before administration

• Dental checkup is advised prior to treatment to reduce risk of jaw complications

• Use caution in patients with asthma, especially aspirin-sensitive individuals

Drug Interactions

Caution is advised when used with:

• Aminoglycosides (may increase risk of hypocalcemia)

• Loop diuretics (may increase risk of dehydration and renal toxicity)

• Nephrotoxic drugs (e.g., NSAIDs)

Storage Information

• Store at 25°C; do not freeze

• Use only clear, particle-free solution

• Discard any unused portion after opening

• Keep out of reach of children

FAQs: Zoledronic Acid Injection (ZOLMIGRAN)

Q1. What is Zoledronic Acid Injection used for?

A: It is used to treat osteoporosis, bone damage from cancer, Paget’s disease, and hypercalcemia due to tumors.

Q2. How is ZOLMIGRAN administered?

A: It is given through IV infusion, typically once a year for osteoporosis or more frequently for cancer-related conditions.

Q3. Can Zoledronic Acid cause jaw problems?

A: Rarely, it may cause osteonecrosis of the jaw. Dental hygiene and preventive dental checkups are advised before starting therapy.

Q4. What should I do if I have flu-like symptoms after the injection?

A: These are common and usually resolve within 2–3 days. Over-the-counter pain relievers like paracetamol may help.

Q5. Is ZOLMIGRAN safe for long-term use?

A: Yes, when used under medical supervision with regular monitoring, it is generally safe and effective for long-term use.

Conclusion

ZOLMIGRAN (Zoledronic Acid Injection 5 mg/100 ml) is a powerful, long-acting bisphosphonate that plays a vital role in preserving bone strength, preventing fractures, and managing cancer-related bone complications. With once-yearly dosing for osteoporosis and proven outcomes in oncology care, ZOLMIGRAN is a trusted choice in modern bone health management.

About The Company

Steris Healthcare Pvt Ltd, widely recognized as Sterispharma, was established in February 2018 by a team of seasoned experts from the pharmaceutical sector. Based in Navi Mumbai, the company is proudly certified by WHO, GMP, and ISO, underscoring its unwavering commitment to quality and patient safety. Sterispharma is driven by a mission to make affordable, premium-quality medicines accessible throughout India, adhering strictly to WHO-recommended standards. Through its user-friendly online pharmacy platforms, customers can effortlessly order medications with home delivery services.

Sterispharma boasts an extensive portfolio of healthcare solutions, ranging from treatments for rare diseases to essential everyday healthcare needs. Their comprehensive product lineup addresses multiple therapeutic areas including Cardiology, Asthma, Respiratory Disorders, Nasal Care, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infective/Antibiotic Therapy, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental Care, and Dermatology. Medications are easily available for online purchase through their official websites — Sterisonline, Sterisindia, and Sterispharma — offering a seamless and reliable healthcare experience.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

BUY NOW