Introduction

What is NAPROXZEN D 500?

NAPROXZEN D 500 is a combination medication containing Naproxen (500mg) and Domperidone SR (30mg). This dual-action formulation is designed to provide relief from pain and inflammation while addressing gastrointestinal discomfort that can be associated with pain-relieving medications like Naproxen. It is commonly used to treat various conditions that involve pain, inflammation, and discomfort, such as arthritis, musculoskeletal pain, and dysmenorrhea (painful menstruation).

• Naproxen (500mg): Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzymes COX-1 and COX-2, which are involved in the production of prostaglandins. Prostaglandins are chemicals in the body that promote inflammation, pain, and fever. By reducing their production, Naproxen helps alleviate pain, swelling, and inflammation.

• Domperidone SR (30mg): Domperidone is a gastroprokinetic agent and an antiemetic that helps in relieving nausea and improving gastric motility. It works by blocking dopamine receptors in the stomach and intestines, which helps to accelerate gastric emptying and reduces nausea and bloating.

The combination of these two active ingredients in NAPROXZEN D 500 provides an effective treatment for both pain and discomfort related to inflammation, while also minimizing the potential for gastric side effects commonly associated with NSAIDs like Naproxen.

Composition of NAPROXZEN D 500

• Active Ingredients:

  • Naproxen (500mg): A powerful NSAID that helps reduce inflammation, pain, and fever by inhibiting the production of prostaglandins.

  • Domperidone SR (30mg): A dopamine antagonist that aids in improving gastric motility and reducing nausea, while helping to prevent stomach irritation that can be caused by NSAIDs like Naproxen.

• Excipients:

  • These are inactive ingredients used in the formulation to ensure stability, proper absorption, and controlled release of the active ingredients.

Formulation:

• Sustained-release (SR) capsule: The sustained-release formulation of Domperidone helps in providing a prolonged effect, maintaining a stable level of the drug in the body for an extended period of time.

Key Features of NAPROXZEN D 500

1. Pain and Inflammation Relief:

   • Naproxen is known for its efficacy in reducing pain and inflammation, making NAPROXZEN D 500 a potent option for individuals with inflammatory conditions like arthritis, gout, or musculoskeletal pain.

2. Reduces Gastrointestinal Discomfort:

   • The inclusion of Domperidone SR in the formulation helps minimize the gastrointestinal side effects (such as nausea, indigestion, and gastritis) commonly associated with NSAIDs like Naproxen. This is especially beneficial for individuals who experience stomach upset when taking other NSAIDs.

3. Sustained-Release Domperidone:

   • The sustained-release (SR) formulation of Domperidone ensures that the medication works gradually, providing long-lasting relief from nausea and helping to improve overall gastric motility.

4. Dual Action for Comprehensive Relief:

   • This combination therapy targets both the pain and inflammation of the condition and the gastrointestinal discomfort, providing a comprehensive approach to symptom management.

5. Effective for Various Conditions:

   • NAPROXZEN D 500 is indicated for a variety of conditions such as arthritis, dysmenorrhea, musculoskeletal injuries, and other pain and inflammatory disorders, making it a versatile medication.

How NAPROXZEN D 500 Works

1. Naproxen (500mg):

   • Naproxen belongs to the class of drugs called NSAIDs (Non-Steroidal Anti-Inflammatory Drugs), and it works by blocking the COX enzymes (Cyclooxygenase 1 and 2). These enzymes are responsible for the production of prostaglandins, which are chemicals that cause pain, fever, and inflammation. By inhibiting these enzymes, Naproxen helps to reduce the production of prostaglandins, thereby alleviating pain, inflammation, and fever.

2. Domperidone SR (30mg):

   • Domperidone is a dopamine antagonist that works by blocking dopamine receptors in the gastrointestinal tract, which helps to enhance gastric motility. This allows food to move through the stomach and intestines more efficiently, thus reducing symptoms like nausea, vomiting, and bloating. The sustained-release formulation of Domperidone helps provide a gradual and continuous effect over time.

Together, the combination of Naproxen and Domperidone SR addresses both pain and the discomfort caused by NSAID use, such as gastric irritation, nausea, and delayed gastric emptying.

Usage of NAPROXZEN D 500

NAPROXZEN D 500 is primarily used to treat conditions that involve both pain and inflammation. It is especially useful for individuals who experience gastrointestinal side effects when using traditional NSAIDs for pain management.

Indications:

• Arthritis (Osteoarthritis, Rheumatoid arthritis, Gout)

• Musculoskeletal Pain (Injury, Sprains, Strains)

• Dysmenorrhea (Painful menstruation)

• Pain and Inflammation Relief (General pain relief from conditions like back pain, tendinitis, or bursitis)

• Post-Surgical Pain (for mild to moderate pain relief)

Dosage:

• Adults: The typical dose of NAPROXZEN D 500 is 1 capsule (500mg Naproxen + 30mg Domperidone SR) once or twice daily, depending on the severity of the condition and the advice of the healthcare provider.

• Children: This medication is not recommended for children. Always consult a doctor before giving any form of Naproxen or Domperidone to children.

Instructions for Use:

• Take with food: It is recommended to take NAPROXZEN D 500 with food to reduce the risk of stomach irritation and to enhance absorption.

• Swallow the capsule whole: Do not crush or chew the capsule, as it is designed for sustained release.

• Consistency: Take the medication at the same time each day to help remember the dosing schedule.

Benefits of NAPROXZEN D 500

1. Dual Action for Pain and Gastrointestinal Comfort:

   • The combination of Naproxen for pain and inflammation relief and Domperidone SR for improving gastric motility and reducing nausea helps manage pain without the common gastrointestinal side effects of traditional NSAIDs.

2. Effective Pain Management:

   • Naproxen is highly effective in treating a variety of pain conditions, including musculoskeletal pain, arthritis, and dysmenorrhea, providing relief that can last for hours.

3. Prevents Gastric Side Effects:

   • The inclusion of Domperidone SR reduces the likelihood of gastric irritation, nausea, or vomiting, common side effects of other NSAIDs, making it easier to tolerate for long-term use.

4. Long-lasting Effects:

   • The sustained-release formulation of Domperidone ensures that gastrointestinal discomfort is minimized for an extended period, while the Naproxen continues to reduce pain and inflammation.

5. Convenient Dosing:

   • NAPROXZEN D 500 is typically taken once or twice a day, which makes it convenient and easy for patients to adhere to their treatment plan.

Side Effects of NAPROXZEN D 500

As with all medications, NAPROXZEN D 500 may cause side effects, although not everyone will experience them. Common and serious side effects include:

Common Side Effects:

• Headache

• Indigestion or heartburn

• Dizziness or lightheadedness

• Abdominal pain, nausea, or vomiting

• Fatigue or drowsiness

Serious Side Effects:

• Gastrointestinal bleeding or ulcers (especially with prolonged use)

• Allergic reactions, including rash, swelling, or shortness of breath

• Severe stomach pain, black or bloody stools, or vomiting blood

• Kidney problems, such as changes in urine output

• Liver dysfunction, including yellowing of the skin or eyes, dark urine, or severe fatigue

Seek medical attention immediately if any of these serious side effects occur.

FAQ Section

1. What is NAPROXZEN D 500 used for?

NAPROXZEN D 500 is used for the treatment of pain and inflammation, such as arthritis, musculoskeletal pain, and dysmenorrhea (painful menstruation). It also helps alleviate gastric discomfort that may be caused by traditional NSAIDs.

2. How does NAPROXZEN D 500 work?

NAPROXZEN D 500 works by combining Naproxen (which reduces pain and inflammation) and Domperidone SR (which helps with gastric motility and reduces nausea), offering comprehensive relief from both pain and gastrointestinal discomfort.

3. Can I take NAPROXZEN D 500 with other medications?

Always consult your doctor before taking NAPROXZEN D 500 with other medications, especially blood thinners, other NSAIDs, or antacids, as there may be interactions.

4. How long does it take for NAPROXZEN D 500 to work?

You should begin to feel relief from pain and inflammation within a few hours of taking NAPROXZEN D 500. Gastrointestinal discomfort may take longer to subside, but the sustained-release formulation of Domperidone SR will help maintain its effects for an extended period.

5. Are there any side effects of NAPROXZEN D 500?

Common side effects include nausea, headache, and abdominal discomfort. Serious side effects include gastrointestinal bleeding, allergic reactions, and kidney or liver issues. Always consult your healthcare provider if you experience any unusual symptoms.

Conclusion

NAPROXZEN D 500 is a dual-action medication that combines Naproxen (500mg) for pain and inflammation relief and Domperidone SR (30mg) for gastric motility and reducing nausea. It is an effective treatment for conditions like arthritis, musculoskeletal pain, and dysmenorrhea, offering both pain relief and protection against gastrointestinal discomfort. By addressing both the pain and the gastric side effects typically associated with NSAIDs, NAPROXZEN D 500 provides a comprehensive approach to managing symptoms.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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