Indapamide Sustained Release 1.5 mg, a thiazide-like diuretic, is included in INDAPAMIX SR 1.5, a prescription antihypertensive medication that is frequently used for the long-term treatment of high blood pressure (hypertension). Indapamide is a recommended option in contemporary cardiovascular therapy because of its dual mechanism, which effectively controls blood pressure with little metabolic disruption.

In India, hypertension is a significant public health issue and a major risk factor for renal disease, heart attacks, and strokes. With once-daily dosage, INDAPAMIX SR 1.5 is intended to provide 24-hour blood pressure management, enhancing patient outcomes and treatment compliance. Because of its sustained-release composition, which guarantees consistent medication levels, abrupt blood pressure swings are minimized.

Physicians in basic care and specialty cardiology frequently utilize INDAPAMIX SR 1.5 due to its shown effectiveness and exceptional tolerability.

Uses

INDAPAMIX SR 1.5 is primarily used for the management of:

1. Hypertension (High Blood Pressure)

The main indication of INDAPAMIX SR 1.5 is the treatment of essential hypertension. By lowering elevated blood pressure, it helps reduce the risk of cardiovascular complications such as heart attack, stroke, and heart failure.

2. Cardiovascular Risk Reduction

Effective long-term blood pressure control with Indapamide contributes to a lower risk of coronary artery disease and cerebrovascular events.

3. Adjunct Therapy in Hypertension

INDAPAMIX SR 1.5 can be used alone or in combination with other antihypertensive agents like ACE inhibitors, ARBs, or calcium channel blockers when monotherapy is insufficient.

Its sustained and smooth action makes it suitable for chronic use in diverse patient populations.

Benefits

INDAPAMIX SR 1.5 offers several clinically significant benefits that support its widespread use:

1. Effective 24-Hour Blood Pressure Control

The sustained-release formulation ensures gradual and consistent reduction in blood pressure throughout the day.

2. Once-Daily Convenience

Single daily dosing improves patient adherence, especially in long-term therapy.

3. Minimal Metabolic Side Effects

Unlike conventional diuretics, Indapamide has minimal impact on blood sugar, lipid profile, and uric acid levels, making it suitable for patients with diabetes or dyslipidaemia.

4. Cardiovascular Protection

By maintaining optimal blood pressure, INDAPAMIX SR 1.5 helps protect vital organs such as the heart, brain, and kidneys.

5. Well-Tolerated in Elderly Patients

The gentle diuretic effect and controlled release make it a preferred option in elderly hypertensive patients.

6. Proven Clinical Efficacy

Indapamide is supported by extensive clinical evidence demonstrating its effectiveness in reducing cardiovascular morbidity and mortality.

These advantages position INDAPAMIX SR 1.5 as a reliable and physician-preferred antihypertensive therapy.

Dosage

The dosage of INDAPAMIX SR 1.5 should always be determined by a qualified healthcare professional.

Recommended Dosage:

• Usual Dose: One tablet of INDAPAMIX SR 1.5 mg once daily, preferably in the morning.

• Administration: The tablet should be swallowed whole with water. It should not be crushed or chewed to maintain the sustained-release effect.

Dose Adjustment:

• Higher doses are generally not recommended, as increasing the dose does not significantly enhance blood pressure control but may increase side effects.

• In elderly patients or those with impaired renal or hepatic function, careful monitoring is advised.

Patients should take the medicine at the same time every day and should not discontinue therapy without medical advice.

Side Effects

INDAPAMIX SR 1.5 is generally well tolerated when taken as prescribed. However, some patients may experience side effects.

Common Side Effects:

• Dizziness or lightheadedness

• Headache

• Fatigue

• Muscle cramps

• Mild gastrointestinal discomfort

Less Common Side Effects:

• Low blood pressure

• Electrolyte imbalance (such as low potassium levels)

• Increased urination, especially during initial treatment

Rare but Serious Side Effects:

• Severe dehydration

• Irregular heartbeat

• Allergic reactions such as rash or itching

Most side effects are mild and resolve with continued use. Regular monitoring helps identify and manage any potential issues early.

Precautions and Warning

Before starting INDAPAMIX SR 1.5, the following precautions should be considered:

1. Electrolyte Monitoring

Indapamide may alter electrolyte levels, especially potassium and sodium. Periodic blood tests are recommended during long-term therapy.

2. Kidney and Liver Disorders

Use with caution in patients with renal or hepatic impairment. Severe kidney disease may contraindicate use.

3. Diabetes and Gout

Although metabolically neutral, careful monitoring is advised in patients with diabetes or a history of gout.

4. Pregnancy and Breastfeeding

INDAPAMIX SR 1.5 should be used during pregnancy or breastfeeding only if clearly needed and under medical supervision.

5. Drug Interactions

Inform the physician about other medications, including antihypertensives, lithium, corticosteroids, or NSAIDs, to avoid interactions.

6. Avoid Dehydration

Adequate fluid intake is essential, especially in hot climates or during illness.

Strict adherence to medical advice ensures safe and effective use of INDAPAMIX SR 1.5.

Conclusion

INDAPAMIX SR 1.5, containing Indapamide Sustained Release 1.5 mg, is a trusted and effective solution for the long-term management of hypertension. Its sustained-release formulation provides consistent blood pressure control with excellent tolerability and minimal metabolic effects.