Introduction

TELAVINCE 300 is a trusted antiviral medication containing Tenofovir Disoproxil Fumarate 300 mg, widely used in the management of HIV-1 infection and chronic Hepatitis B virus (HBV) infection. Manufactured under WHO-GMP certified facilities, TELAVINCE 300 delivers consistent potency, safety, and therapeutic efficacy, making it a first-choice medicine in antiretroviral therapy.

What is Tenofovir Disoproxil Fumarate?

Tenofovir Disoproxil Fumarate (TDF) is a nucleotide reverse transcriptase inhibitor (NtRTI). Once inside the body, it is converted into tenofovir diphosphate, which works by blocking the reverse transcriptase enzyme. This enzyme is essential for the replication of HIV and Hepatitis B viruses. By inhibiting this process, Tenofovir reduces viral multiplication, decreases viral load, and helps protect the immune system and liver.

Uses of Tenofovir Disoproxil Fumarate Tablets 300 mg

1. HIV-1 Infection

   • Used in adults and adolescents (≥12 years, weighing ≥35 kg).

   • Always prescribed in combination with other antiretroviral medicines.

   • Helps reduce viral load and increase CD4 cell count.

2. Chronic Hepatitis B Virus (HBV) Infection

   • Used in patients with active HBV replication and liver disease.

   • Helps prevent complications like cirrhosis and liver cancer.

Mechanism of Action

• After administration, Tenofovir Disoproxil Fumarate converts into tenofovir diphosphate.

• It competes with natural nucleotides during viral DNA synthesis.

• This leads to premature chain termination, stopping viral replication.

• As a result, the viral load decreases and disease progression slows down.

Dosage and Administration

• Adults & Adolescents (≥12 years, ≥35 kg): 300 mg tablet once daily with food.

• For HIV Treatment: Always given with other antiretroviral agents.

• For Chronic Hepatitis B: Can be used as monotherapy or in combination.

• Renal Impairment: Dose adjustment required; kidney function monitoring is essential.

 Always follow the doctor’s prescribed dosage and do not stop medication suddenly.

Benefits of Tenofovir Disoproxil Fumarate

•  Strong and sustained antiviral activity against HIV and HBV
•  Convenient once-daily tablet for patient compliance
•  Proven to improve immune function (CD4 count) in HIV patients
•  Reduces risk of liver complications in Hepatitis B patients
•  Included in WHO and national treatment guidelines

Side Effects of Tenofovir Disoproxil Fumarate

While most patients tolerate it well, some may experience:

• Nausea, vomiting, or diarrhea

• Headache and dizziness

• Fatigue or weakness

• Rash or skin irritation

• Decrease in bone mineral density (long-term use)

• Kidney-related issues (rare)

 Contact your doctor if side effects are severe or persistent.

Safety and Precautions

• Kidney Monitoring: Regular renal function tests are necessary.

• Bone Health: Monitor bone density in patients at risk of osteoporosis.

• Hepatitis B Patients: Sudden discontinuation may cause a flare of hepatitis.

• Pregnancy & Breastfeeding: Should be used only under medical advice.

• Drug Interactions: Inform your doctor about all other medicines you are taking.

Storage Instructions

• Store below 30°C in a cool, dry place.

• Protect from light and moisture.

• Keep away from children’s reach.

Price of Tenofovir Disoproxil Fumarate Tablets 300 mg in India

The price of Tenofovir 300 mg tablets in India generally ranges between ₹1,200 for a pack of 30 tablets (one-month treatment). Cost may vary depending on the brand and manufacturer.

FAQs on Tenofovir Disoproxil Fumarate Tablets

1. What are Tenofovir Disoproxil Fumarate tablets used for?
They are used to treat HIV-1 infection and chronic Hepatitis B virus infection.

2. Can Tenofovir cure HIV or Hepatitis B?
No. It helps control the virus, prevent complications, and improve quality of life, but it is not a cure.

3. How long should I take Tenofovir 300 mg tablets?
Treatment is usually long-term or lifelong, depending on your condition and doctor’s advice.

4. Can I stop taking Tenofovir suddenly?
No. Stopping the medicine suddenly can cause serious flare-ups of HIV or Hepatitis B. Always consult your doctor first.

5. Is Tenofovir safe during pregnancy?
Yes, it may be prescribed during pregnancy, but only under strict medical supervision.

Conclusion

Tenofovir Disoproxil Fumarate Tablets IP 300 mg are among the most important antiviral medicines for the management of HIV-1 and Hepatitis B. With strong efficacy, once-daily dosing, and proven clinical outcomes, it remains a first-line therapy worldwide. Patients should use it strictly under a doctor’s supervision, with regular monitoring to ensure safety and effectiveness.