Managing type 2 diabetes mellitus (T2DM) often requires a combination of medications targeting different mechanisms in the body. One such powerful combination therapy includes Teneligliptin 20mg, Pioglitazone 15mg, and Extended Release Metformin Hydrochloride 500mg. This triple drug combination is gaining attention among healthcare professionals for its efficacy, tolerability, and ability to address multiple metabolic defects in diabetes.

What are Teneligliptin, Pioglitazone, and Metformin?

This triple combination is designed for patients who do not achieve adequate glycemic control with single or dual therapy. Let’s understand the function of each component:

1. Teneligliptin 20mg

Teneligliptin belongs to the DPP-4 inhibitor class of antidiabetic agents. It works by increasing the levels of incretin hormones, which enhance insulin secretion and suppress glucagon release, ultimately lowering blood glucose levels.

Teneligliptin 20mg Uses:

• Management of type 2 diabetes mellitus in adults.

• Often used when monotherapy with Metformin or other antidiabetics fails.

• Helps in improving post-prandial and fasting glucose levels.
   

2. Pioglitazone 15mg

Pioglitazone is a thiazolidinedione that works by improving insulin sensitivity in adipose tissue, muscle, and the liver. It helps reduce insulin resistance—a major issue in T2DM.

3. Extended Release Metformin Hydrochloride 500mg

Metformin Hydrochloride 500 mg is a first-line agent for T2DM and is well-known for its glucose-lowering effects without causing hypoglycemia. The extended-release version helps maintain more stable drug levels throughout the day, reducing gastrointestinal side effects.

How the Combination Works Together

Combining Teneligliptin 20mg Tab, Pioglitazone 15mg, and Extended Release Metformin Hydrochloride 500mg offers a multi-targeted approach:

• Teneligliptin increases insulin secretion and decreases glucagon.

• Pioglitazone enhances insulin sensitivity in peripheral tissues.

• Metformin suppresses hepatic glucose production and improves peripheral glucose uptake.
   

This synergy results in better glycemic control with minimal risk of hypoglycemia, especially suitable for individuals with moderate to severe insulin resistance.

Clinical Benefits of the Combination

Improved Glycemic Control

This triple combination effectively lowers HbA1c levels and fasting plasma glucose, even in patients with high baseline glucose.

Better Insulin Sensitivity

Thanks to Pioglitazone 15 mg, insulin resistance is addressed, helping patients with long-standing diabetes.

Low Risk of Hypoglycemia

Since Teneligliptin and Metformin do not cause insulin release directly, the risk of hypoglycemia is minimal unless used with insulin or sulfonylureas.

Convenient Once-Daily Dosing

The availability in a fixed-dose combination simplifies treatment regimens, enhancing patient adherence.

Dosage and Administration

The usual recommended dose of this combination is:

• One tablet daily (preferably with meals), containing:
   

  • Teneligliptin 20mg

  • Pioglitazone 15mg

  • Metformin Hydrochloride Extended Release 500mg

However, dosage should be individualized by the prescribing physician based on patient response, kidney function, and tolerance.

Side Effects and Safety Profile

Like all medications, this combination may cause side effects. Some of the commonly reported ones include:

Common Side Effects:

• Nausea or stomach upset (from Metformin)

• Weight gain or fluid retention (due to Pioglitazone)

• Headache or sore throat (from Teneligliptin)

• Flatulence, abdominal discomfort
   

Serious But Rare Side Effects:

• Lactic acidosis – a rare but serious risk from Metformin

• Heart failure – Pioglitazone should be used cautiously in patients with heart disease

• Bladder cancer risk (rare and controversial) – with long-term Pioglitazone use

• Pancreatitis – a rare risk associated with DPP-4 inhibitors
   

It's essential to monitor renal and liver function periodically while on this medication.

Who Should Not Take This Combination?

This combination is not recommended for:

• Patients with type 1 diabetes or diabetic ketoacidosis

• People with severe renal or hepatic impairment

• Pregnant or lactating women

• Those with a history of bladder cancer or active heart failure
   

Always consult a physician before starting or stopping any antidiabetic regimen.

Lifestyle Recommendations with This Combination

For best results, this combination should be taken along with:

• Balanced diet rich in fiber and low in refined sugars

• Regular physical activity, such as walking, yoga, or resistance training

• Routine blood sugar monitoring to assess treatment effectiveness

• Weight control to improve insulin sensitivity

Drug Interactions

When using Teneligliptin 20mg Metformin Hydrochloride 500 mg with other medications, be aware of potential interactions:

• Diuretics may increase the risk of lactic acidosis.

• Alcohol can enhance the effect of Metformin and should be limited.

• Insulin or sulfonylureas can increase the risk of hypoglycemia.

• NSAIDs may affect kidney function, requiring close monitoring.

Always inform your doctor about any other medications or supplements you're taking. 

Why Choose Steris Healthcare For TENELIGOLD PM 500 ? 

Choosing the right healthcare partner is crucial when managing chronic conditions like type 2 diabetes, and Steris Healthcare stands out as a trusted name in the pharmaceutical industry. TENELIGOLD PM 500, a powerful combination of Teneligliptin 20mg, Pioglitazone 15mg, and Extended Release Metformin Hydrochloride 500mg, is one of Steris Healthcare’s advanced formulations designed for optimal diabetes control. This triple-action therapy addresses multiple metabolic pathways—enhancing insulin sensitivity, reducing hepatic glucose output, and increasing incretin hormone activity.

Steris Healthcare ensures each batch of TENELIGOLD PM 500 is manufactured with strict quality controls, adhering to global GMP standards. The formulation is developed with patient convenience in mind, offering once-daily dosing for improved compliance. Moreover, Steris Healthcare prioritizes safety, efficacy, and affordability, making TENELIGOLD PM 500 an accessible solution for diabetic patients across India.

What further sets Steris Healthcare apart is its commitment to continuous innovation, ethical practices, and patient education. With a strong distribution network and dedicated customer support, Steris ensures that healthcare providers and patients receive timely access to essential medications.