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Sitagliptin 100 mg, Metformin SR 500 mg & Pioglitazone 15 mg in Triple Diabetes Therapy

Feb 23, 2026

ST GLIPTIN 3D 500 is a powerful triple-combination medicine used for the management of Type 2 Diabetes Mellitus. It contains three well-known anti-diabetic ingredients — Sitagliptin 100 mg, Metformin Hydrochloride 500 mg (Sustained Release), and Pioglitazone 15 mg — which work together to control high blood sugar levels effectively.

In India, diabetes is growing rapidly due to unhealthy food habits, sedentary lifestyle, stress, and genetic factors. Many patients struggle to maintain proper blood sugar levels even after taking one or two medicines. In such cases, doctors may recommend a triple therapy like ST GLIPTIN 3D 500 for better and long-term control.

This medicine is specially designed to target blood sugar from different angles. It helps reduce fasting sugar, post-meal sugar, and HbA1c levels when taken regularly as advised. Along with proper diet, exercise, and regular check-ups, Sitagliptin 100 Pioglitazone 15 Metformin 500 supports better diabetes management and reduces the risk of complications.

Uses

ST GLIPTIN 3D 500 is prescribed for:

Type 2 Diabetes Mellitus

Sitagliptin and metformin hydrochloride tablets uses in adults with Type 2 diabetes who are unable to achieve proper sugar control with diet, exercise, or dual therapy.

Poorly Controlled Blood Sugar

Doctors recommend this combination when:

  • Blood sugar levels remain high

  • HbA1c is above the target range

  • Two-drug therapy is not sufficient

Long-Term Sugar Management

It aids in preserving steady blood sugar levels all day long.

Diabetic ketoacidosis and Type 1 diabetes cannot be treated with this medication.

Benefits

ST GLIPTIN 3D 500 provides triple-action control for better results.

1. Three Medicines in One Tablet

Instead of taking three separate tablets, patients get the benefit of all three medicines in a single combination, which improves convenience and compliance.

2. Controls Sugar Through Multiple Mechanisms

  • Sitagliptin increases insulin release when blood sugar is high and reduces excess glucose production.

  • Metformin SR decreases glucose production in the liver and improves insulin sensitivity.

  • Pioglitazone helps the body respond better to insulin.

This combined action ensures better and more stable sugar control.

3. Sustained Release Advantage

The Metformin component is in sustained-release form, which:

  • Reduces stomach irritation

  • Provides gradual sugar control

  • Improves patient comfort

4. Reduces Risk of Diabetes Complications

Proper sugar control lowers the risk of:

  • Heart disease

  • Kidney damage

  • Nerve problems

  • Eye complications

5. Suitable for Indian Lifestyle

Indian diets often include high carbohydrates. This triple therapy supports better glucose management even with dietary challenges, when combined with proper lifestyle changes.

Dosage

Always take Sitagliptin and metformin hydrochloride tablets exactly as prescribed by your doctor.

General Guidelines

  • Usually taken once daily or as advised.

  • Take with food to avoid stomach upset.

  • Swallow the tablet whole with water.

  • Do not crush or chew the sustained-release tablet.

Important Instructions

  • Take it at the same time every day.

  • Do not skip doses.

  • Avoid stopping the drug suddenly without first talking to your doctor.

Your doctor may adjust the dose depending on your blood sugar levels and overall health condition.

Side Effects

Most patients tolerate ST GLIPTIN 3D 500 well. However, some mild side effects may occur.

Common Side Effects

  • Nausea

  • Stomach discomfort

  • Diarrhoea

  • Headache

  • Mild weight gain

  • Cold-like symptoms

Less Common Side Effects

  • Swelling of feet or ankles

  • Low blood sugar (especially when taken with insulin or other medicines)

  • Dizziness

Rare but Serious Side Effects

  • Severe abdominal pain

  • Signs of heart failure

  • Lactic acidosis (rare but serious condition linked with Metformin)

As soon as you notice any strange symptoms, speak with your doctor.

Regular monitoring of blood sugar, kidney function, and liver function is recommended.

Warning and Precautions

Before starting ST GLIPTIN 3D 500, inform your doctor if you have:

  • Kidney problems

  • Liver disease

  • Heart disease

  • History of pancreatitis

  • Bladder cancer

  • Severe infection

Pregnancy and Breastfeeding

Before taking this medication while pregnant or nursing, speak with your doctor.

Alcohol Consumption

Avoid excessive alcohol intake as it may increase the risk of low blood sugar and lactic acidosis.

Low Blood Sugar Risk

Although this medicine does not usually cause severe hypoglycemia alone, risk increases when used with insulin or certain other medicines.

Regular Check-Ups

Patients should:

  • Monitor blood sugar regularly

  • Follow recommended diet and exercise

  • Get periodic HbA1c tests

Never self-medicate or adjust the dose without medical guidance.

About Steris Healthcare

Steris Healthcare is a trusted pharmaceutical company committed to delivering high-quality and affordable medicines across India. The company focuses on patient safety, innovation, and strict quality standards.

Steris Healthcare follows modern manufacturing practices and quality control measures to ensure reliable and effective medicines. With a wide range of healthcare products, the company aims to support doctors and patients in managing chronic diseases like diabetes.

By offering advanced formulations such as sitagliptin and metformin hydrochloride, Steris Healthcare continues to contribute to better healthcare outcomes for Indian patients.

Frequently Asked Questions (FAQ)

1. What is ST GLIPTIN 3D 500 used for?

It is used for managing Type 2 diabetes in adults who need stronger blood sugar control.

2. How does this medicine work?

It combines three anti-diabetic medicines that work in different ways to control blood sugar levels effectively.

3. Can I take this medicine without food?

It is better to take it with food to reduce stomach discomfort.

4. Does it cause low blood sugar?

On its own, the risk is low. However, when combined with insulin or other medicines, low sugar levels may occur.

5. Is it safe for long-term use?

Yes, when taken under medical supervision, it is safe for long-term diabetes management.

6. Can I stop the medicine once sugar levels are normal?

No. Because blood sugar levels can rise again, don't stop without first talking to your doctor.

7. What lifestyle changes should I follow?

Maintain a balanced diet, exercise regularly, avoid sugary foods, manage stress, and go for regular check-ups.

Conclusion

ST GLIPTIN 3D 500, containing Sitagliptin 100 mg, Metformin Hydrochloride 500 mg (SR), and Pioglitazone 15 mg, offers strong and effective triple-action support for managing Type 2 Diabetes Mellitus. It helps control fasting and post-meal sugar levels while improving insulin response.

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