Introduction

PANTOSTRUM CT is a combination therapy used for the treatment of gastrointestinal disorders, particularly those involving acid reflux, delayed gastric emptying, and functional dyspepsia. It includes:

• Pantoprazole 40 mg – a proton pump inhibitor (PPI) that reduces stomach acid production.

• Cinitapride SR 3 mg – a gastroprokinetic agent in sustained-release form, which enhances gastrointestinal motility.

This dual-action approach helps relieve both acid-related symptoms (like heartburn and GERD) and motility-related issues (like bloating, fullness, and indigestion), making it especially effective in conditions like GERD with delayed gastric emptying, or functional dyspepsia.

Composition

Uses of PANTOSTRUM CT

PANTOSTRUM CT is prescribed in the management of:

1. Gastroesophageal Reflux Disease (GERD)

• Controls acid reflux and promotes faster gastric emptying, reducing symptoms like heartburn and regurgitation.

2. Functional Dyspepsia

• Treats symptoms like early satiety, bloating, and upper abdominal discomfort.

3. Delayed Gastric Emptying (Gastroparesis)

• Enhances stomach muscle contractions to promote timely food movement into the intestines.

4. Postprandial Distress Syndrome

• Alleviates fullness and discomfort after eating.

5. Peptic Ulcer Disease (PUD)

• Reduces acid to allow healing of ulcers, especially when motility is impaired.

Benefits of PANTOSTRUM CT

• Dual Mechanism: Combines acid suppression and improved gut motility in one tablet.

• Symptom Relief: Effective for multiple overlapping GI symptoms.

• Sustained-Release Action: Provides long-lasting control of motility symptoms.

• Improved Compliance: Single daily dose for ease of use.

Mechanism of Action

• Pantoprazole: A PPI that inhibits the H⁺/K⁺ ATPase pump in the gastric parietal cells, thereby reducing acid secretion.

• Cinitapride: Acts as a 5-HT₄ receptor agonist and D₂ receptor antagonist, enhancing the release of acetylcholine and promoting coordinated gastrointestinal motility.

Side Effects

While generally well-tolerated, PANTOSTRUM CT may cause:

Common Side Effects:

• Headache

• Diarrhea or constipation

• Abdominal discomfort

• Flatulence

• Nausea

Less Common/Serious Side Effects:

• Dizziness

• Rash or allergic reactions

• Long-term Pantoprazole use may lead to:

  • Vitamin B12 deficiency

  • Magnesium deficiency

  • Increased risk of bone fractures

• Cinitapride-related effects (rare):

  • Extrapyramidal symptoms (involuntary movements)

Always report unusual or persistent symptoms to your doctor.

Drug Information

Safety Advice

General Guidelines:

• Dosage: Usually taken once daily before breakfast.

• Swallow whole: Do not crush or chew, especially due to the sustained-release and enteric-coated nature.

• Missed Dose: Take it as soon as you remember. If close to the next dose, skip the missed one. Do not double the dose.

Special Precautions:

• Pregnancy & Breastfeeding: Use only if clearly prescribed. Limited safety data.

• Elderly Patients: May need monitoring for long-term side effects (e.g., bone health, electrolyte levels).

• Kidney/Liver Impairment: Dose adjustments may be required in severe impairment.

Drug Interactions:

• Pantoprazole:

  • May reduce absorption of drugs requiring stomach acid (e.g., ketoconazole, iron).

  • May affect warfarin or digoxin levels.

• Cinitapride:

  • Avoid concurrent use with anticholinergic drugs (may counteract its effect).

  • Use with caution if taking CNS drugs.

FAQs – Frequently Asked Questions

Q1: When should I take PANTOSTRUM CT?
It should be taken once daily, preferably 30 minutes before breakfast.

Q2: Can I take this medication long-term?
It may be used for extended periods under medical supervision. Long-term use requires periodic evaluation, especially for nutrient deficiencies and bone health.

Q3: Will this medication help with gas and bloating?
Yes, the prokinetic action of Cinitapride can relieve bloating and fullness by improving gastric emptying.

Q4: Can I drink alcohol while taking this?
Alcohol can irritate the stomach lining and worsen GI symptoms. It is advisable to limit alcohol consumption.

Q5: Is this safe for diabetic patients with gastroparesis?
Yes, under supervision. It may help with gastric emptying in diabetics experiencing gastroparesis, but blood sugar levels should be monitored.

Conclusion

PANTOSTRUM CT, combining Pantoprazole  and Cinitapride , offers a comprehensive approach to gastrointestinal symptom management by reducing stomach acid and enhancing gut motility. It is especially beneficial for patients with overlapping disorders like GERD, functional dyspepsia, and delayed gastric emptying.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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