Introduction

Pentoxifylline (400mg), marketed as OXIFYLINE PR 400, is a pharmaceutical agent primarily used to improve blood flow in patients suffering from circulation disorders. This medication belongs to the class of drugs known as xanthine derivatives and is widely recognized for its ability to reduce blood viscosity, enhance microcirculation, and increase oxygen delivery to tissues. OXIFYLINE PR 400 is commonly prescribed for conditions such as peripheral arterial disease (PAD), intermittent claudication, cerebrovascular insufficiency, and diabetic angiopathy.

Key Ingredients

The active component in OXIFYLINE PR 400 is Pentoxifylline (400mg), which works as a hemorheologic agent to enhance red blood cell deformability, thereby reducing blood viscosity and improving circulation.

Mechanism of Action

Pentoxifylline (400mg) exerts its effects through several mechanisms:

1. Improvement of Blood Flow: It decreases blood viscosity and increases red blood cell flexibility, leading to improved circulation in microcapillaries.

2. Anti-inflammatory Effects: It helps reduce inflammation in blood vessels, preventing complications related to circulatory disorders.

3. Increased Oxygen Supply: By improving blood flow, it ensures better oxygen delivery to tissues, which is essential for individuals suffering from ischemic conditions.

4. Inhibition of Platelet Aggregation: It reduces the tendency of platelets to clump together, lowering the risk of blood clots and associated complications.

Uses of OXIFYLINE PR 400

1. Peripheral Arterial Disease (PAD)

Pentoxifylline (400mg) is commonly prescribed for PAD, a condition in which narrowed arteries reduce blood flow to the limbs, leading to pain, cramping, and mobility issues.

2. Intermittent Claudication

A key indication for OXIFYLINE PR 400 is intermittent claudication, a symptom of PAD characterized by muscle pain and cramps during exercise due to poor blood circulation.

3. Cerebrovascular Insufficiency

Patients experiencing inadequate blood supply to the brain may benefit from Pentoxifylline (400mg), which improves microcirculation and oxygenation in the brain, reducing the risk of cognitive decline and strokes.

4. Diabetic Angiopathy

Diabetic patients with vascular complications can use OXIFYLINE PR 400 to prevent tissue hypoxia and ulcer formation.

5. Venous Insufficiency

It is also beneficial in chronic venous insufficiency, reducing edema and improving blood flow in affected veins.

Dosage and Administration

• The typical dosage for OXIFYLINE PR 400 is 400mg taken three times daily after meals.

• It should be swallowed whole with water and not crushed or chewed.

• Dosage adjustments may be required for individuals with renal or hepatic impairments.

Side Effects

While Pentoxifylline (400mg) is generally well-tolerated, some individuals may experience side effects, including:

• Nausea and Vomiting

• Dizziness and Headache

• Gastrointestinal Discomfort

• Hypotension (Low Blood Pressure)

• Allergic Reactions (Rash, Itching, Swelling)

• Tachycardia (Rapid Heartbeat)

Patients should seek medical attention if severe reactions occur, such as chest pain, difficulty breathing, or signs of an allergic response.

Precautions and Warnings

• Not recommended for individuals with severe bleeding disorders due to its effect on platelet aggregation.

• Caution in patients with cardiovascular diseases as it may cause fluctuations in blood pressure.

• Should not be used by pregnant or breastfeeding women without medical consultation.

• Patients taking anticoagulants or blood thinners should be monitored closely to prevent excessive bleeding.

Drug Interactions

OXIFYLINE PR 400 may interact with various medications, including:

• Anticoagulants (Warfarin, Heparin) – Increases bleeding risk.

• Antihypertensive Drugs – May lead to an excessive drop in blood pressure.

• Caffeine-containing medications – May enhance central nervous system stimulation.

• Theophylline – Can lead to increased side effects.

Storage and Handling

• Store OXIFYLINE PR 400 at room temperature, away from direct sunlight and moisture.

• Keep out of reach of children and pets.

• Do not use expired medication.

Price in India

The Price of Pentoxifylline (400mg) – OXIFYLINE PR 400 in India varies based on brand and pharmacy location. On average, a strip of 10 tablets is priced between ₹150 – ₹300. Patients are advised to check with local pharmacies or online platforms for the latest pricing.

Conclusion

Pentoxifylline (400mg), available as OXIFYLINE PR 400, is an essential medication for individuals suffering from circulation-related disorders. By improving blood flow, reducing inflammation, and preventing complications such as PAD, intermittent claudication, cerebrovascular insufficiency, and diabetic angiopathy, it plays a crucial role in vascular health. Proper dosage, adherence to precautions, and awareness of potential side effects are key to maximizing the benefits of OXIFYLINE PR 400.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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