Fenofibrate 145 mg, a well-known fibrate family medication used mainly to treat dyslipidemia and hypertriglyceridemia, is included in the prescription lipid-lowering medication FENOFIBRON 145. It promotes the breakdown of triglycerides, decreases the synthesis of very-low-density lipoprotein (VLDL), and raises the levels of high-density lipoprotein (HDL) cholesterol via activating peroxisome proliferator-activated receptor alpha (PPAR-α).

FENOFIBRON 145 is intended to lower the risk of cardiovascular events, such as heart attacks and strokes, by assisting individuals with aberrant lipid profiles in achieving healthy cholesterol levels. Healthcare professionals in India who treat patients with lipid problems now favor it due to its easy once-daily dosage and shown effectiveness.

Dyslipidemia is a major risk factor for atherosclerosis and cardiovascular disease, and Fenofibrate therapy is an essential component of long-term cardiovascular risk management.

Uses

FENOFIBRON 145 is indicated for the treatment of various lipid disorders and associated conditions:

1. Hypertriglyceridemia

FENOFIBRON 145 effectively reduces elevated triglyceride levels, which are associated with an increased risk of pancreatitis and cardiovascular complications.

2. Mixed Dyslipidemia

It is used in patients with combined lipid disorders, characterized by high triglycerides, elevated LDL cholesterol, and low HDL cholesterol.

3. Cardiovascular Risk Reduction

By improving the lipid profile, FENOFIBRON 145 reduces the risk of coronary heart disease and other atherosclerotic events, especially in high-risk patients with diabetes or metabolic syndrome.

4. Adjunct to Diet and Lifestyle

FENOFIBRON 145 is prescribed alongside dietary modifications, exercise, and weight management programs to achieve optimal lipid control.

5. Familial Hypertriglyceridemia

Patients with genetic lipid disorders benefit from Fenofibrate therapy to lower triglycerides and prevent complications.

By targeting multiple aspects of dyslipidemia, FENOFIBRON 145 provides comprehensive lipid management, supporting overall cardiovascular health.

Benefits

FENOFIBRON 145 offers multiple clinical and patient-centric benefits:

1. Effective Triglyceride Reduction

Fenofibrate reduces triglyceride levels significantly, which is crucial for preventing pancreatitis and cardiovascular disease.

2. Increase in HDL Cholesterol

It helps raise HDL (“good”) cholesterol, improving the lipid balance and providing additional cardiovascular protection.

3. Reduction of LDL Cholesterol

Although primarily effective for triglycerides, Fenofibrate also lowers LDL cholesterol in patients with mixed dyslipidemia.

4. Cardiovascular Risk Management

Improved lipid profiles contribute to lower risk of atherosclerosis, heart attacks, and stroke, particularly in patients with metabolic syndrome or diabetes.

5. Convenient Once-Daily Dosing

The 145 mg tablet allows once-daily administration, enhancing adherence in chronic therapy.

6. Evidence-Based Efficacy

Fenofibrate is supported by extensive clinical research demonstrating its effectiveness in managing lipid disorders and reducing cardiovascular events.

These benefits make FENOFIBRON 145 a reliable choice for physicians aiming to achieve comprehensive lipid management and long-term cardiovascular protection.

Dosage

The dosage of FENOFIBRON 145 should be determined by a healthcare professional based on the patient’s lipid profile, age, and clinical condition.

Recommended Dosage:

• Typical Dose: One tablet of FENOFIBRON 145 mg once daily, preferably taken with food to enhance absorption.

• Administration: Swallow the tablet whole with water. Avoid splitting or crushing, as this may affect bioavailability.

Dose Adjustments:

• Patients with renal impairment may require dose modification based on creatinine clearance.

• The dosage may be adjusted in elderly patients or those with multiple comorbidities.

• Regular monitoring of lipid profile, liver function, and kidney function is recommended during therapy.

Consistent adherence to the prescribed dosage ensures maximum therapeutic benefit while minimizing the risk of adverse effects.

Side Effects

FENOFIBRON 145 is generally well-tolerated, but some patients may experience side effects.

Common Side Effects:

• Gastrointestinal discomfort, including nausea, indigestion, or abdominal pain

• Mild headache

• Muscle pain or cramps (myalgia)

• Fatigue or dizziness

Less Common but Serious Side Effects:

• Liver enzyme elevation

• Rhabdomyolysis (rare but serious muscle breakdown)

• Gallstones or biliary complications

• Severe allergic reactions, including rash or swelling

Patients experiencing severe or persistent symptoms should seek immediate medical attention. Early detection of adverse effects allows timely dose adjustments and ensures continued therapy safety.

Precautions and Warning

Before prescribing FENOFIBRON 145, the following precautions should be considered:

1. Liver and Kidney Function

Patients with hepatic or renal impairment require close monitoring. Liver function tests should be performed prior to therapy initiation and periodically thereafter.

2. Muscle Disorders

Patients with a history of muscle disorders or previous statin-induced myopathy should be carefully monitored, as Fenofibrate may increase the risk of muscle-related side effects.

3. Drug Interactions

FENOFIBRON 145 may interact with statins, anticoagulants, immunosuppressants, or other lipid-lowering agents. Inform your physician about all ongoing medications.

4. Pregnancy and Breastfeeding

Fenofibrate should only be used during pregnancy or lactation if clearly indicated and under strict medical supervision.

5. Lifestyle Modifications

FENOFIBRON 145 is most effective when combined with dietary interventions, regular exercise, and weight management to achieve optimal lipid control.

Adherence to these precautions ensures safe, effective, and long-term management of lipid disorders.

Conclusion

FENOFIBRON 145, containing Fenofibrate 145 mg, is a potent and clinically proven therapy for the management of hypertriglyceridemia, mixed dyslipidemia, and cardiovascular risk reduction. Its mechanism of action targets multiple aspects of lipid metabolism, improving triglycerides, HDL, and LDL cholesterol levels.