Introduction

Doxofylline 400 mg brand name DX PHYLLIN 400 is a widely prescribed methylxanthine derivative used in the management of respiratory disorders such as asthma, chronic bronchitis, and COPD (Chronic Obstructive Pulmonary Disease). Unlike theophylline, it offers better tolerability, fewer side effects, and safer long-term use.

Composition of DX PHYLLIN 400

• Active Ingredient: Doxofylline 400 mg

• Dosage Form: Sustained Release (SR) tablet

• Therapeutic Class: Xanthine derivative, bronchodilator

Mechanism of Doxofylline

Doxofylline works as a bronchodilator by relaxing the smooth muscles of the airways, thereby improving airflow to the lungs.

• It inhibits phosphodiesterase (PDE) enzymes, increasing intracellular cAMP levels, which causes bronchial muscle relaxation.

• Unlike theophylline, it shows minimal cardiac stimulation and CNS-related adverse effects, making it safer for long-term use.

• It also has anti-inflammatory properties, which reduce airway inflammation in asthma and COPD patients.

Uses of Doxofylline (Doxofylline 400 mg Uses)

Doxofylline 400 mg tablets are primarily prescribed for:

1. Asthma – Prevention and management of bronchospasms.

2. Chronic Bronchitis – Relief from cough and difficulty in breathing.

3. COPD (Chronic Obstructive Pulmonary Disease) – Improvement in airflow and lung function.

4. Emphysema – Helps reduce breathlessness.

5. Pulmonary disorders with reversible airway obstruction.

Indications of Doxofylline

• Moderate to severe asthma

• Chronic bronchitis

• Chronic obstructive pulmonary disease (COPD)

• Pulmonary emphysema

• As an adjunct therapy in respiratory rehabilitation programs

Method of Administration of Doxofylline

• Route: Oral administration

• Form: Tablet (Sustained Release)

• Administration advice:

  • Take with water, preferably after meals, to minimize gastric irritation.

  • Swallow the tablet whole; do not crush or chew.

  • Dosage must be strictly as per the physician’s prescription.

Dosage Strength of Doxofylline

• Available strengths:

  • Doxofylline 200 mg tablets

  • Doxofylline 400 mg tablets (DX PHYLLIN 400)

Dosage Form of Doxofylline

• Tablets (SR form) – most commonly used

• Injection – available for acute management in hospital settings

Dietary Restrictions and Safety Advice of Doxofylline

• Avoid alcohol – increases risk of side effects.

• Limit caffeine intake (coffee, tea, cola, chocolate) – may worsen insomnia, palpitations.

• Avoid smoking – reduces the effectiveness of the drug.

• Maintain a balanced diet rich in fruits, vegetables, and antioxidants for better lung function.

Contraindications of Doxofylline

Doxofylline should be avoided in patients with:

• Known hypersensitivity to doxofylline or xanthine derivatives

• Severe heart disease (arrhythmias, recent myocardial infarction)

• Severe liver impairment

• Hypotension or severe hypertension

• Epilepsy or seizure disorders

Adverse Reactions of Doxofylline

While generally well tolerated, adverse reactions may occur, especially at higher doses:

• Mild gastrointestinal issues: Nausea, vomiting, abdominal discomfort

• Neurological issues: Headache, dizziness, insomnia, restlessness

• Cardiac issues: Tachycardia, palpitations, arrhythmia (rare but serious)

• Hypersensitivity reactions: Rash, itching, urticaria

• Rare events: Hypokalemia, liver enzyme elevation

Side Effects of Doxofylline 400 mg

Some common and rare side effects of Doxofylline tablets (DX PHYLLIN 400) include:

• Headache

• Dizziness

• Nausea & vomiting

• Epigastric pain

• Palpitations

• Tremors

• Insomnia or disturbed sleep

• Irritability or nervousness

• Skin rash or itching

• Increased urination

• Rare: Arrhythmia, seizures (in overdose), hypokalemia, hypotension

Note: Side effects are dose-dependent and usually less severe compared to theophylline.

Drug Interaction of Doxofylline

Doxofylline may interact with:

• Beta-blockers (reduce the bronchodilation effect)

• Corticosteroids (may enhance hypokalemia)

• Diuretics (increased risk of electrolyte imbalance)

• Fluoroquinolone antibiotics (ciprofloxacin, enoxacin – may increase toxicity)

• Antiepileptic drugs (phenytoin, carbamazepine – alter drug levels)

• Oral contraceptives (can reduce metabolism of doxepin)

Clinical Studies of Doxofylline

• Clinical trials show comparable bronchodilation efficacy to theophylline with fewer cardiac and CNS side effects.

• Long-term studies demonstrate significant improvement in FEV1 (Forced Expiratory Volume in 1 second) among COPD patients.

• Better compliance reported due to once or twice-daily dosing with sustained release formulations.

• Considered safer in elderly patients and those with cardiovascular risks compared to traditional xanthines.

Why Choose Steris Healthcare Pvt. Ltd. for Doxofylline 400 mg?

When it comes to reliable respiratory medicines like DX PHYLLIN 400 (Doxofylline 400 mg), Steris Healthcare Pvt. Ltd. stands out as a trusted pharmaceutical partner:

• WHO-GMP Certified Manufacturing, ensuring the highest quality standards.

• Affordable pricing for patients across India.

• Wide distribution network making medicines easily accessible.

• Extensive product portfolio covering respiratory, cardiac, and chronic care therapies.

• Commitment to innovation and patient safety.

Choosing Steris Healthcare means choosing quality, affordability, and trust.

Conclusion

Doxofylline 400 mg tablets (DX PHYLLIN 400) are a safe and effective bronchodilator used in asthma, COPD, chronic bronchitis, and emphysema. With its unique mechanism of action, better tolerability, and fewer side effects than theophylline, it is widely preferred by doctors.However, it must be taken only under medical supervision, with adherence to dosage, dietary restrictions, and monitoring for side effects. For patients and healthcare providers seeking reliable and high-quality Doxofylline medicines, Steris Healthcare Pvt. Ltd. offers trusted solutions that ensure better respiratory health and improved quality of life.

FAQs on Doxofylline 400 mg

1. What is Doxofylline 400 mg used for?
It is used to treat asthma, COPD, chronic bronchitis, and emphysema by relaxing airway muscles and improving breathing.

2. Is Doxofylline safer than Theophylline?
Yes, it has fewer cardiac and central nervous system side effects compared to theophylline.

3. What is the dosage of Doxofylline 400 mg?
Usually 1 tablet twice daily, but dosage must be prescribed by a doctor.

4. Can Doxofylline be taken with food?
Yes, it should be taken after meals to avoid gastric irritation.

5. What are the common side effects of Doxofylline?
Headache, nausea, dizziness, insomnia, and palpitations are the most reported side effects.

6. Is Doxofylline safe in pregnancy?
It should be used with caution; consult a doctor before use.

7. What is the price of Doxofylline 400 mg tablet?
Prices vary depending on brand and location, but Steris Healthcare Pvt. Ltd. ensures affordable and accessible options.