GLIDAPAFLOZIN M 5/500 is a thoughtfully formulated combination therapy designed to support better blood sugar control in adults living with Type 2 Diabetes Mellitus. The tablet blends Dapagliflozin 5 mg, a selective SGLT2 inhibitor, with Metformin 500 mg, one of the most trusted first-line anti-diabetic medicines. Together, they target different pathways involved in elevated blood glucose, helping patients achieve steady glycemic control with improved long-term outcomes.

In India, where Type 2 Diabetes is increasingly prevalent, combination medicines like GLIDAPAFLOZIN M 5/500 play a significant role in simplifying treatment and improving compliance. With its dual mechanism—reducing glucose absorption in the kidneys and decreasing glucose production in the liver—the formulation supports better HbA1c reduction, weight management, and improved metabolic health.

What Is GLIDAPAFLOZIN M 5/500?

GLIDAPAFLOZIN M 5/500 contains two active ingredients:

• Dapagliflozin 5 mg: A Sodium-Glucose Cotransporter-2 (SGLT2) inhibitor that helps the kidneys eliminate excess glucose through urine.

• Metformin 500 mg: A biguanide that reduces hepatic glucose production and enhances insulin sensitivity.

This combination is widely prescribed for patients whose blood sugar remains uncontrolled on Metformin alone or those who need intensified therapy for better glycemic management.

How GLIDAPAFLOZIN M 5/500 Works

1. Role of Dapagliflozin (5mg)

Dapagliflozin reduces blood sugar levels by blocking SGLT2 proteins in the kidneys. These proteins are responsible for reabsorbing glucose back into the bloodstream. By inhibiting them, the medicine allows excess glucose to leave the body through urine, which helps:

• Lower fasting and postprandial sugar

• Reduce HbA1c levels

• Support weight loss

• Reduce blood pressure in some patients

• Improve overall glycemic control

2. Role of Metformin (500mg)

Metformin works through two primary pathways:

• Decreases the liver’s glucose production

• Enhances the body’s sensitivity to insulin

Together, the combination improves the body’s natural ability to regulate blood sugar.

Uses of GLIDAPAFLOZIN M 5/500

Doctors prescribe this combination for:

• Type 2 Diabetes Mellitus

• Patients with poor glycemic control on Metformin alone

• Overweight diabetic patients needing weight-friendly therapy

• Patients requiring oral combination therapy

• Reduction in diabetes-related complications when used with lifestyle changes

This tablet is not recommended for Type 1 Diabetes or diabetic ketoacidosis.

Benefits of GLIDAPAFLOZIN M 5/500

1. Effective Blood Sugar Reduction

The combination significantly lowers FBS, PPBS, and HbA1c levels, leading to better glucose management.

2. Weight Management Support

Dapagliflozin helps reduce excess sugar and calories through urine, promoting natural weight loss—an important benefit for Indian patients struggling with obesity-related diabetes.

3. Reduced Cardiovascular Risk

Studies show SGLT2 inhibitors may reduce the risk of heart failure and improve cardiovascular outcomes in high-risk patients.

4. Improved Metabolic Health

Metformin boosts insulin sensitivity, and Dapagliflozin improves kidney glucose clearance, offering dual metabolic benefits.

5. Convenient Dual Therapy

Instead of taking separate tablets, patients get a single combination dose, enhancing compliance.

6. Lower Risk of Hypoglycemia

When taken alone, both medicines have a lower chance of causing sudden blood sugar drops, making therapy safer.

Dosage and How to Take GLIDAPAFLOZIN M 5/500

• Take one tablet daily, or as directed by your physician.

• Preferably consumed with meals to reduce gastric discomfort caused by Metformin.

• Swallow whole with water; do not crush or chew.

• Maintain a fixed schedule for better blood glucose control.

The dosage may vary based on your sugar levels, medical history, and kidney function.

Possible Side Effects

Like all medicines, GLIDAPAFLOZIN M 5/500 may cause some mild to moderate side effects. Common ones include:

With Dapagliflozin

• Increased urination

• Genital fungal infections

• Urinary tract infections

• Dehydration or thirst

With Metformin

• Nausea or stomach upset

• Diarrhoea

• Metallic taste

• Abdominal discomfort

Most side effects are temporary and improve as the body adjusts. However, consult your doctor immediately if symptoms worsen.

Precautions & Safety Information

Before starting GLIDAPAFLOZIN M 5/500, patients should consider the following:

1. Kidney Function

Dapagliflozin is not recommended for patients with severe kidney issues. Dose adjustments may be needed.

2. Alcohol Consumption

Limit alcohol to avoid the risk of lactic acidosis associated with Metformin.

3. Hydration

Drink adequate water to avoid dehydration from increased urination.

4. Heart & Liver Conditions

Inform your doctor if you have any chronic illnesses.

5. Pregnancy & Breastfeeding

Should be taken only if prescribed by a specialist.

6. Surgery or Stress Conditions

Blood sugar may fluctuate during illness; dose modification might be necessary.

Why Choose GLIDAPAFLOZIN M 5/500?

• Clinically effective dual therapy

• Weight-friendly diabetes management

• Ideal for Indian patients with uncontrolled sugar

• Supports better heart and kidney health

• Helps improve long-term metabolic outcomes

This product is designed to offer strong glycemic control, simplified dosing, and added health benefits.

Lifestyle Tips for Better Results

To enhance the effectiveness of GLIDAPAFLOZIN M 5/500:

• Follow a balanced, diabetic-friendly diet

• Include daily exercise or brisk walking

• Maintain hydration

• Monitor blood sugar regularly

• Avoid smoking and excess alcohol

Combining the tablet with lifestyle modification ensures better sugar control and overall wellness.

Conclusion

GLIDAPAFLOZIN M 5/500, containing Dapagliflozin 5 mg and Metformin 500 mg, is a powerful, reliable, and patient-friendly therapy for Type 2 Diabetes management. Its dual action delivers effective sugar control, supports weight loss, and provides added cardiovascular benefits—making it an excellent choice for long-term diabetes care. When used under medical guidance along with healthy lifestyle practices, this combination can significantly improve quality of life and reduce diabetes-related complications.