Living with pulmonary arterial hypertension (PAH) can be challenging, as it affects breathing, daily activities, and overall quality of life. One of the most effective treatment approaches is the Ambrisentan + Tadalafil combination (5 mg + 20 mg), marketed by Steris Healthcare under the trusted brand name AMBRISTAR 5 + DURA 20 (COMBO).

This combination therapy is carefully designed to improve blood flow in the lungs, reduce high pressure in pulmonary arteries, and enhance exercise capacity in patients with PAH.

What is Ambrisentan + Tadalafil Combination?

Ambrisentan is an endothelin receptor antagonist (ERA), while Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor. Together, they provide a dual mechanism of action that improves pulmonary vascular health.

• Ambrisentan 5 mg works by blocking endothelin, a natural substance that causes blood vessels to constrict. By doing so, it relaxes and widens the pulmonary arteries.
   
• Tadalafil 20 mg increases nitric oxide effects in the body, leading to vasodilation (widening of blood vessels) and reducing pulmonary artery pressure.

The result is better oxygen delivery, reduced strain on the heart, and improved stamina.

Uses of Ambrisentan + Tadalafil Combination

1. Treatment of Pulmonary Arterial Hypertension (PAH)
   Helps reduce pressure in pulmonary arteries and improves symptoms.
    
2. Improves Exercise Capacity
   Enables patients to engage in physical activity with less shortness of breath.
    
3. Slows Disease Progression
   Prevents worsening of PAH and supports long-term heart and lung health.
    
4. Enhances Quality of Life
   Patients experience better energy levels, reduced fatigue, and improved daily functioning.
    

How Does Ambrisentan + Tadalafil Work Together?

The combination provides complementary benefits:

• Ambrisentan reduces vessel constriction caused by endothelin.
   
• Tadalafil boosts vasodilation and blood flow by increasing cGMP levels.

This dual action therapy decreases pulmonary pressure, helps the right side of the heart pump more effectively, and lowers the risk of PAH-related complications.

Side Effects of Ambrisentan + Tadalafil Combination

While generally well-tolerated, some patients may experience:

• Headache or dizziness
• Flushing
• Stuffy nose or sinus pain
• Swelling of hands, legs, or feet (edema)
• Nausea or indigestion

Rare but serious side effects may include liver function changes, vision problems, or severe low blood pressure. Regular monitoring and medical supervision are essential.

Precautions Before Taking Ambrisentan + Tadalafil

• Not recommended for pregnant or breastfeeding women.
• Inform your doctor if you have liver or kidney disease.
• Avoid combining with nitrates or certain blood pressure medications.
• Patients with low blood pressure should use caution.
• Regular liver function tests and hemoglobin monitoring may be required.
   

Why Choose Steris Healthcare’s AMBRISTAR 5 + DURA 20 (COMBO)?

Choosing the right treatment partner is as important as the medicine itself. Steris Healthcare ensures:

• WHO-GMP Certified Manufacturing – Global standard quality and safety.
• Clinically Reliable Formulation – Designed to deliver consistent therapeutic results.
• Pan-India Availability – Ensuring timely access for patients everywhere.
• Trusted Healthcare Partner – Recommended by doctors for reliable patient care.
   

With AMBRISTAR 5 + DURA 20 (COMBO), patients not only get advanced treatment for PAH but also the trust and assurance of Steris Healthcare.

FREQUENTLY ASKED QUESTION

1. What is Ambrisentan + Tadalafil used for?
It is used for the treatment of pulmonary arterial hypertension (PAH) to improve exercise capacity and slow disease progression.

2. How should I take Ambrisentan + Tadalafil tablets?
Take it as prescribed by your doctor, usually once daily, with or without food.

3. Can I drink alcohol with Ambrisentan + Tadalafil?
It is best to avoid alcohol, as it may increase dizziness and lower blood pressure.

4. How long does it take to see results?
Some improvement may be seen within a few weeks, but full benefits may take a few months.

5. Is this combination safe for long-term use?
Yes, under medical supervision, it can be safely used for long-term management of PAH.

Conclusion

AMBRISTAR 5 + DURA 20 (COMBO), the trusted Ambrisentan + Tadalafil combination (5 mg + 20 mg) from Steris Healthcare, is a proven and effective treatment for pulmonary arterial hypertension. By lowering pulmonary pressure, improving oxygen supply, and enhancing exercise tolerance, it gives patients a chance to live with renewed strength and confidence.

With Steris Healthcare’s dedication to quality, safety, and patient care, you can trust this therapy to make a real difference in managing PAH.